2-Propenoic acid, 3-chloro-, methyl ester, (2Z)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-chloro-, methyl ester, (2Z)-
• CAS No.: 3510-44-9
• Molecular Formula: C4H5ClO2
• Molecular Weight: 120.535
• Mol file: 3510-44-9.mol

Synonyms:Z-β-Chloroacrylic acid methyl ester;methyl cis-3-chloroacrylate;methyl cis-2-chloroacrylate;methyl Z-2-chloroacrylate;methyl Z-3-chlorocrotonate;(Z)-3-chloro-2-propenoic acid methyl ester;

Chemical Property of 2-Propenoic acid, 3-chloro-, methyl ester, (2Z)-

Chemical Property:

• Boiling Point: 124.1±13.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 0.91190

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-chloro-, methyl ester, (2Z)-

There total 1 articles about 2-Propenoic acid, 3-chloro-, methyl ester, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propynoic acid methyl ester (922-67-8) → methyl-trans-3-chloroacrylate (5135-18-2) + methyl cis-2-chloroacrylate (3510-44-9)

Guidance literature:

With hydrogenchloride; In methanol; Title compound not separated from byproducts;

Reference yield: 93.0%

methyl cis-2-chloroacrylate (3510-44-9) + (3-cyclohexylpropyl)-malonic acid diethyl ester (76731-02-7) → (E)-4-(3-Cyclohexyl-propyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester (250721-81-4)

Guidance literature:

(3-cyclohexylpropyl)-malonic acid diethyl ester; With sodium hydride; In tetrahydrofuran; for 0.166667h;

methyl cis-2-chloroacrylate; In tetrahydrofuran; for 14h; Heating;

DOI:10.1021/jm990309x

Reference yield: 92.0%

methyl cis-2-chloroacrylate (3510-44-9) + diethyl 2-(4-butylcyclohexyl)malonate (82012-64-4) → (E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester (250721-82-5)

Guidance literature:

diethyl 2-(4-butylcyclohexyl)malonate; With sodium hydride; In tetrahydrofuran; for 0.166667h;

methyl cis-2-chloroacrylate; In tetrahydrofuran; for 14h; Heating;

DOI:10.1021/jm990309x

upstream raw materials:

propynoic acid methyl ester

Downstream raw materials:

methyl 3,3-dimethoxypropionate

1',5',7',8'-tetrahydrospiro<1,3-dioxolane-2,6'(2'H)-quinolin>-2'-one

3-Chlor-2-cyclohexylpropansaeure-methylester

3-Chlor-3-cyclohexylpropansaeure-methylester

Refernces