1-METHYL-2-(DIPHENYLPHOSPHINO)TEREPHTHA&

Base Information

• Chemical Name: 1-METHYL-2-(DIPHENYLPHOSPHINO)TEREPHTHA&
• CAS No.: 361154-31-6
• Molecular Formula: C21H17O4P
• Molecular Weight: 364.337
• Mol file: 361154-31-6.mol

Synonyms:2-(diphenylphosphino)-4-(methoxycarbonyl)benzoic acid;2-Diphenylphosphanyl-terephthalic acid 1-methyl ester;2-diphenylphosphonylterephthalic acid 1-methyl ester;1-Methyl-2-diphenyl phosphinoterephthalate;1,4-Benzenedicarboxylicacid,2-(diphenylphosphino)-,1-methylester;2-(diphenylphosphino)terephthalic acid 1-methyl ester;3-(diphenylphosphino)-4-(methoxycarbonyl) benzoic acid;1-methyl-2-(diphenylphosphino)terephthalate;1-methyl-2-diphenylphosphinoterephthalate;

Chemical Property of 1-METHYL-2-(DIPHENYLPHOSPHINO)TEREPHTHA&

Chemical Property:

• Melting Point: 201-206?°C
• Boiling Point: 530.2±45.0 °C(Predicted)
• PKA: 3.66±0.10(Predicted)
• PSA: 77.19000
• LogP: 2.92960

Purity/Quality:

98%Min ^*data from raw suppliers

1,4-BENZENEDICARBOXYLIC ACID, 2-(DIPHENYLPHOSPHINO)-,1-METHYL ESTER 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-2-(DIPHENYLPHOSPHINO)TEREPHTHA&

There total 3 articles about 1-METHYL-2-(DIPHENYLPHOSPHINO)TEREPHTHA& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-methyl-2-diphenylphosphinoterephthalate oxide (1172624-01-9) → 3-(diphenylphosphino)-4-(methoxycarbonyl)benzoic acid (361154-31-6)

Guidance literature:

With trichlorosilane; triethylamine; In toluene; for 6h; Reflux; Inert atmosphere;

DOI:10.1039/b822420j

Reference yield: 94.0%

diphenylphosphane (829-85-6) + [3-iodo-4-(methoxycarbonyl)]benzoic acid (299173-24-3) → 3-(diphenylphosphino)-4-(methoxycarbonyl)benzoic acid (361154-31-6)

Guidance literature:

With palladium diacetate; triethylamine; In methanol; for 10h; Inert atmosphere; Reflux;

DOI:10.1016/j.polymer.2016.01.066

Reference yield:

1-methyl-2-aminoterephthalate (60728-41-8) → 3-(diphenylphosphino)-4-(methoxycarbonyl)benzoic acid (361154-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂; KI

2: palladium acetate; NEt₃ / acetonitrile / 5 h / 85 °C

With palladium diacetate; triethylamine; potassium iodide; sodium nitrite; In acetonitrile;

DOI:10.1246/cl.2004.580

upstream raw materials:

diphenylphosphane

[3-iodo-4-(methoxycarbonyl)]benzoic acid

1-methyl-2-aminoterephthalate

1-methyl-2-diphenylphosphinoterephthalate oxide

Downstream raw materials:

2-(diphenylphosphino)terephthalic acid 1-methyl 4-pentafluorophenyl diester

N-(3-{2-[2-(3-tert-Butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-2-diphenylphosphanyl-terephthalamic acid methyl ester

2-(diphenylphosphanyl)terephthalic acid 1-methyl ester 4-(N-succinimidyl) ester

1-methyl-2-diphenylphosphinoterephthalate oxide

Refernces

• 1、 Sallouh, Omar,Weberskirch, Ralf. "Facile formation of hydrogels by using functional precursor polymers and the chemoselective Staudinger coupling". . p. 189 - 196. Retrieved 2016/02/18.
• 2、 Gobbo, Pierangelo,Gunawardene, Praveen,Luo, Wilson,Workentin, Mark S.. "Synthesis of a toolbox of clickable rhodamine B derivatives". supporting information. p. 1169 - 1174. Retrieved 2015/03/31.