1-(1,2-Diphenylethyl)piperidine

Base Information

• Chemical Name: 1-(1,2-Diphenylethyl)piperidine
• CAS No.: 36794-52-2
• Molecular Formula: C19H23N
• Molecular Weight: 265.398
• Hs Code.: 2933399090
• UNII: H8Q4VPL82Y
• DSSTox Substance ID: DTXSID50724547
• Nikkaji Number: J2.366.921H
• Wikipedia: Diphenidine
• Wikidata: Q15708284
• ChEMBL ID: CHEMBL4303426
• Mol file: 36794-52-2.mol

Synonyms:1-(1,2-diphenylethyl)piperidine;diphenidine

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Chemical Property of 1-(1,2-Diphenylethyl)piperidine

Chemical Property:

• Vapor Pressure: 7.83E-13mmHg at 25°C
• Boiling Point: 547.8oC at 760 mmHg
• Flash Point: 285.1oC
• PSA: 77.84000
• LogP: 4.10600
• Storage Temp.: Store at RT
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 265.183049738
• Heavy Atom Count: 20
• Complexity: 257

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C(CC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-(1,2-Diphenylethyl)piperidine

There total 16 articles about 1-(1,2-Diphenylethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-benzoylpiperidine (776-75-0) + benzylmagnesium chloride (6921-34-2) → (±)-1-(1,2-diphenylethyl)piperidine (36794-52-2)

Guidance literature:

N-benzoylpiperidine; With bis(triphenylphosphine)carbonyliridium(I) chloride; 1,1,3,3-Tetramethyldisiloxane; In dichloromethane; at 20 ℃; for 0.333333h;

benzylmagnesium chloride; at -78 - 20 ℃; for 4h; chemoselective reaction;

DOI:10.1039/c7sc03613b

Reference yield: 77.0%

piperidine (110-89-4) + benzyl bromide (100-39-0) + benzaldehyde (100-52-7) → (±)-1-(1,2-diphenylethyl)piperidine (36794-52-2)

Guidance literature:

piperidine; benzyl bromide; benzaldehyde; With trifluoroacetic acid; zinc; In acetonitrile; for 1.5h; Inert atmosphere;

With ammonium chloride; In water; acetonitrile;

DOI:10.1021/jo901704s

Reference yield: 46.0%

1,1'-benzylidenedipiperidine (2538-76-3) + benzyl bromide (100-39-0) → (±)-1-(1,2-diphenylethyl)piperidine (36794-52-2)

Guidance literature:

With chloro-trimethyl-silane; diisopropylamine; zinc; In benzene; at 20 ℃; for 6h;

DOI:10.1021/jo8019797

upstream raw materials:

1-(butoxyphenylmethyl)piperidine

phenylmagnesium bromide

benzylmagnesium chloride

piperidine

Downstream raw materials:

(+/-)-1-(1,2-diphenylethyl)piperidine hydrochloride

Refernces

• 1、 Xie, Lan-Gui,Dixon, Darren J.. "Tertiary amine synthesis: Via reductive coupling of amides with Grignard reagents". . p. 7492 - 7497. Retrieved 2017/10/30.
• 2、 Berger, Michael L.,Schweifer, Anna,Rebernik, Patrick,Hammerschmidt, Friedrich. "NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds". experimental part. p. 3456 - 3462. Retrieved 2009/09/30.