L-CYSTINE DIHYDROCHLORIDE

Base Information

• Chemical Name: L-CYSTINE DIHYDROCHLORIDE
• CAS No.: 30925-07-6
• Molecular Formula: C₆H₁₂N₂O₄S₂*2ClH
• Molecular Weight: 313.226
• Hs Code.: 29309013
• Mol file: 30925-07-6.mol

Synonyms:Cystine,dihydrochloride, L- (8CI);L-Cystine, dihydrochloride (9CI);Cystinedihydrochloride;L-cystine dihydrochloride;L-cystine, hydrochloride (1:2);

Chemical Property of L-CYSTINE DIHYDROCHLORIDE

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0Pa at 20℃
• Melting Point: 228-232℃
• Boiling Point: 505.5 °C at 760 mmHg
• Flash Point: 259.5 °C
• PSA: 177.24000
• Density: 1.518[at 20℃]
• LogP: 2.19620
• Storage Temp.: Store at RT.
• Solubility.: 0.5 M HCl: 50 mg/mL
• Water Solubility.: Soluble in hydrochloric acid. (0.5 M HCl: 50 mg/mL) Soluble in water.

Purity/Quality:

98% ^*data from raw suppliers

L-Cystine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: L-Cystine is a sulfur containing non-essential amino acid. It is used as a cell culture media component and raw material in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Cystine dihydrochloride is a modified version of L-Cystine with improved solubility.

Technology Process of L-CYSTINE DIHYDROCHLORIDE

There total 1 articles about L-CYSTINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

l-cysteine hydrochloride (52-89-1) → L-cystine dihydrochloride (13059-63-7,30925-07-6,34760-60-6,55533-01-2,62152-64-1,90350-38-2)

Guidance literature:

With dihydrogen peroxide; sodium iodide; In water; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.1c02608

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + L-cystine dihydrochloride (13059-63-7,30925-07-6,34760-60-6,55533-01-2,62152-64-1,90350-38-2) → di-t-butoxycarbonyl-L-cystine (10389-65-8)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201905905

Reference yield: 75.0%

L-cystine dihydrochloride (13059-63-7,30925-07-6,34760-60-6,55533-01-2,62152-64-1,90350-38-2) + Boc-Phe-ONSu (3674-06-4) → 3,3′-disulfanediylbis(2-(2-amino-3-phenylpropanamido)propanoic acid) dihydrochloride

Guidance literature:

L-cystine dihydrochloride; Boc-Phe-ONSu; With triethylamine; In N,N-dimethyl-formamide;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 2h;

DOI:10.1021/acs.biomac.5b00680

upstream raw materials:

l-cysteine hydrochloride

Downstream raw materials:

S-Cyclohexylthio-L-cystein

C₂₀H₁₈N₄O₄S

di-t-butoxycarbonyl-L-cystine

N,N'-bis(tert-butoxy)carbonyl-L-cystine dimethyl ester

Refernces