methylprednisolone 17-hemisuccinate

Base Information

• Chemical Name: methylprednisolone 17-hemisuccinate
• CAS No.: 77074-42-1
• Molecular Formula: C26H34 O8
• Molecular Weight: 474.551
• Mol file: 77074-42-1.mol

Synonyms:methylprednisolone 17-hemisuccinate

Chemical Property of methylprednisolone 17-hemisuccinate

Chemical Property:

• Vapor Pressure: 2.15E-21mmHg at 25°C
• Boiling Point: 679.6°C at 760 mmHg
• PKA: 4.40±0.17(Predicted)
• Flash Point: 226.9°C
• PSA: 138.20000
• Density: 1.33g/cm³
• LogP: 2.21930
• Storage Temp.: Refrigerator
• Solubility.: Dioxane (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

6α-MethylPrednisolone17-Hemisuccinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Methyl Prednisolone (M325934).

Technology Process of methylprednisolone 17-hemisuccinate

There total 2 articles about methylprednisolone 17-hemisuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6α-methylprednisolone-21-hydrogen succinate (2921-57-5) → 6α-methylprednisolone 17-hemisuccinate (77074-42-1)

Guidance literature:

With water; In acetonitrile; at 25 ℃; Rate constant;

DOI:10.1002/jps.2600720431

Reference yield:

6α-methylprednisolone-21-hydrogen succinate (2921-57-5) → Methylprednisolone (83-43-2) + 6α-methylprednisolone 17-hemisuccinate (77074-42-1)

Guidance literature:

With aq. buffer; In N,N-dimethyl-formamide; at 25 ℃; Rate constant; Mechanism; pH dependence;

DOI:10.1002/jps.2600730507

Reference yield:

6α-methylprednisolone 17-hemisuccinate (77074-42-1) → Methylprednisolone (83-43-2) + 6α-methylprednisolone-21-hydrogen succinate (2921-57-5)

Guidance literature:

With aq. buffer; In N,N-dimethyl-formamide; at 25 ℃; Rate constant; Mechanism; pH dependence;

DOI:10.1002/jps.2600730507

upstream raw materials:

6α-methylprednisolone-21-hydrogen succinate

Downstream raw materials:

Methylprednisolone

6α-methylprednisolone-21-hydrogen succinate

Refernces

• 1、 Anderson,Conradi,Lambert. "Carboxyl group catalysis of acyl transfer reactions in corticosteroid 17- and 21-monoesters". . p. 604 - 610. Retrieved 2007/10/02.