4-((4-Fluorophenyl)sulfonyl)morpholine

Base Information

• Chemical Name: 4-((4-Fluorophenyl)sulfonyl)morpholine
• CAS No.: 383-23-3
• Molecular Formula: C10H12FNO3S
• Molecular Weight: 245.275
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10353837
• Nikkaji Number: J3.211.726K
• Wikidata: Q82131649
• Mol file: 383-23-3.mol

Synonyms:383-23-3;4-((4-Fluorophenyl)sulfonyl)morpholine;4-(4-FLUOROPHENYLSULFONYL)MORPHOLINE;4-(4-fluorophenyl)sulfonylmorpholine;4-(4-fluorobenzenesulfonyl)morpholine;4-[(4-fluorophenyl)sulfonyl]morpholine;MFCD00194713;C10H12FNO3S;4-(4-Fluoro-benzenesulfonyl)-morpholine;Oprea1_459391;Oprea1_875406;F0808-1710;SCHEMBL2769910;DTXSID10353837;LDBBCISSYGDVIH-UHFFFAOYSA-N;STK414857;AKOS000273180;4-Fluorobenzenesulfonic acid morpholide;AM86922;NCGC00181903-01;4-(4-Fluorobenzene-1-sulfonyl)morpholine;BS-25123;CS-0452005;EN300-24120;N11591;A873864;AE-641/02612046;Z45515798

Chemical Property of 4-((4-Fluorophenyl)sulfonyl)morpholine

Chemical Property:

• PSA: 54.99000
• LogP: 1.86530
• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 245.05219258
• Heavy Atom Count: 16
• Complexity: 313

Purity/Quality:

95% ^*data from raw suppliers

4-(4-Fluorophenylsulfonyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1S(=O)(=O)C2=CC=C(C=C2)F

Technology Process of 4-((4-Fluorophenyl)sulfonyl)morpholine

There total 12 articles about 4-((4-Fluorophenyl)sulfonyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + 4-Fluorobenzenesulfonyl chloride (349-88-2) → 4-[(4-fluorophenyl)sulfonyl]morpholine (383-23-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 23 ℃; Inert atmosphere;

DOI:10.1002/anie.201707274

Reference yield: 93.0%

4-(benzoyloxy)morpholine (5765-65-1) + sodium 4-fluorobenzenesulfinate (824-80-6) → 4-[(4-fluorophenyl)sulfonyl]morpholine (383-23-3)

Guidance literature:

4-(benzoyloxy)morpholine; sodium 4-fluorobenzenesulfinate; In 1,2-dichloro-ethane; at 30 ℃; for 12h; Schlenk technique; Inert atmosphere;

With copper(ll) bromide; In 1,2-dichloro-ethane; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c5cc06069a

Reference yield: 89.0%

morpholine (110-91-8,99108-56-2) + 1-fluoro-4-[(4-fluorobenzenesulfonyl)sulfanyl]benzene (2905-15-9) → 4-[(4-fluorophenyl)sulfonyl]morpholine (383-23-3)

Guidance literature:

With N-Bromosuccinimide; caesium carbonate; In ethanol; at 80 ℃; for 16h; Sealed tube;

DOI:10.1021/acs.joc.6b03016

upstream raw materials:

morpholine

4-Fluorobenzenesulfonyl chloride

sodium 4-fluorobenzenesulfinate

4-(benzoyloxy)morpholine

Downstream raw materials:

1-cyclohexyl-6-(1-(4-(morpholinosulfonyl)phenyl)azetidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

bis[4-(morpholine-4-sulfonyl)benzene]disulfide

N-[4-(morpholin-4-ylsulfonyl)phenyl]guanidine

p-(sulphonylmorpholino)phenylhydrazine

Refernces

• 1、 Chung Leung, Gulice Yiu,Ramalingam, Balamurugan,Loh, Gabriel,Chen, Anqi. "Efficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated on Demand". . p. 546 - 554. Retrieved 2020/04/22.
• 2、 Chen, Yiding,Murray, Philip R. D.,Davies, Alyn T.,Willis, Michael C.. "Direct Copper-Catalyzed Three-Component Synthesis of Sulfonamides". supporting information. p. 8781 - 8787. Retrieved 2018/07/29.