BENZYL-(2-METHOXY-BENZYL)-AMINE

Base Information

• Chemical Name: BENZYL-(2-METHOXY-BENZYL)-AMINE
• CAS No.: 69875-89-4
• Molecular Formula: C15H17NO
• Molecular Weight: 227.306
• Hs Code.: 2922199090
• Mol file: 69875-89-4.mol

Synonyms:N-(2-Methoxybenzyl)benzylamine;NSC 128933;N-[(2-methoxyphenyl)methyl]-1-phenylmethanamine;N-benzyl-1-(2-methoxyphenyl)methanamine;benzenemethanamine, 2-methoxy-N-(phenylmethyl)-;N-Benzyl-1-(2-methoxyphenyl)methanamine;

Chemical Property of BENZYL-(2-METHOXY-BENZYL)-AMINE

Chemical Property:

• Vapor Pressure: 0.000118mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 335.7 °C at 760 mmHg
• Flash Point: 139.8 °C
• PSA: 21.26000
• Density: 1.053 g/cm³
• LogP: 3.37590

Purity/Quality:

98%min ^*data from raw suppliers

Benzyl-(2-methoxy-benzyl)-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Benzyl-(2-methoxy-benzyl)-amine can be used to prepare for pesticides and for antibacterial compounds to resist yeast-like fungi.

Technology Process of BENZYL-(2-METHOXY-BENZYL)-AMINE

There total 13 articles about BENZYL-(2-METHOXY-BENZYL)-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ortho-anisaldehyde (135-02-4) + benzylamine (100-46-9) → N-benzyl-1-(2-methoxyphenyl)methanamine (69875-89-4)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 100 ℃; for 14h; Flow reactor;

DOI:10.1126/science.aat0650

Reference yield: 76.0%

N-benzyl-2-methoxylbenzamide (183198-63-2) → N-benzyl-1-(2-methoxyphenyl)methanamine (69875-89-4)

Guidance literature:

With 1,1,3,3-Tetramethyldisiloxane; [((CH₃)5C₅)IrCl((CH₃)2NC₆H₃C₅H₄N)]; trityl tetrakis(pentafluorophenyl)borate; In 1,1,2,2-tetrachloroethane; at 100 ℃; for 2h; chemoselective reaction; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1002/cctc.201700400

Reference yield: 76.0%

2-methoxybenzylamine (6850-57-3) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyl-1-(2-methoxyphenyl)methanamine (69875-89-4) + (2-Methoxy-benzyl)-[1-phenyl-meth-(E)-ylidene]-amine

Guidance literature:

With C₂₆H₃₀N₂NiO₃; sodium hydroxide; In toluene; for 20h; Reflux; Molecular sieve; Inert atmosphere;

DOI:10.1021/acs.organomet.1c00552

upstream raw materials:

(E)-N-benzyl-1-(2-methoxyphenyl)methanimine

ortho-anisaldehyde

benzylamine

2-Chlorobenzyl alcohol

Downstream raw materials:

N-benzylidene benzylamine

N-benzyl-N-(2-methoxybenzyl)-2-phenylpropanamide

N-benzyl-N-(2-methoxybenzyl)-2-phenylacetamide

Octanedioic acid bis-({5-[benzyl-(2-methoxy-benzyl)-carbamoyl]-pentyl}-amide)

Refernces

• 1、 Han, Zhangang,Hao, Zhiqiang,Lin, Jin,Lu, Guo-Liang,Zhang, Junhua,Zhang, Xiaoying. "Nickel Complexes Bearing N,N,O-Tridentate Salicylaldiminato Ligand: Efficient Catalysts for Imines Formation via Dehydrogenative Coupling of Primary Alcohols with Amines". . p. 3843 - 3853. Retrieved 2021/11/18.
• 2、 Bédard, Anne-Catherine,Adamo, Andrea,Aroh, Kosi C.,Russell, M. Grace,Bedermann, Aaron A.,Torosian, Jeremy,Yue, Brian,Jensen, Klavs F.,Jamison, Timothy F.. "Reconfigurable system for automated optimization of diverse chemical reactions". . p. 1220 - 1225. Retrieved 2018/10/04.