2-acetyl-4-methylphenyl 4-chlorobenzoate

Base Information

• Chemical Name: 2-acetyl-4-methylphenyl 4-chlorobenzoate
• CAS No.: 4010-22-4
• Molecular Formula: C16H13 Cl O3
• Molecular Weight: 288.73
• Mol file: 4010-22-4.mol

Synonyms:Benzoicacid, p-chloro-, ester with2'-hydroxy-5'-methylacetophenone (7CI,8CI)

Chemical Property of 2-acetyl-4-methylphenyl 4-chlorobenzoate

Chemical Property:

• Vapor Pressure: 1.4E-08mmHg at 25°C
• Boiling Point: 458.2°Cat760mmHg
• Flash Point: 185.6°C
• Density: 1.241g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetyl-4-methylphenyl 4-chlorobenzoate

There total 4 articles about 2-acetyl-4-methylphenyl 4-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-methyl-2-hydroxyacetophenone (1450-72-2) + 4-chloro-benzoyl chloride (122-01-0) → 1-[2-(4-chlorobenzoyloxy)-5-methylphenyl]-ethanone (4010-22-4)

Guidance literature:

With pyridine; at 0 ℃;

DOI:10.1016/j.tetlet.2011.10.134

Reference yield: 65.0%

5-methyl-2-hydroxyacetophenone (1450-72-2) + para-chlorotoluene (106-43-4) → 1-[2-(4-chlorobenzoyloxy)-5-methylphenyl]-ethanone (4010-22-4)

Guidance literature:

With tert.-butylhydroperoxide; copper(II) acetate dihydrate; In decane; at 120 ℃; for 4h; chemoselective reaction;

DOI:10.1021/ol401682a

Reference yield:

para-chlorobenzoic acid (74-11-3) → 1-[2-(4-chlorobenzoyloxy)-5-methylphenyl]-ethanone (4010-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: pyridine / 0 °C

With pyridine; thionyl chloride;

DOI:10.1016/j.tetlet.2011.10.134

upstream raw materials:

5-methyl-2-hydroxyacetophenone

4-chloro-benzoyl chloride

para-chlorobenzoic acid

para-chlorotoluene

Downstream raw materials:

2-(4-chlorophenyl)-6-methyl-4H-chromen-4-one

1a,7a-Dihydro-5-methyl-1a-(4-chlorophenyl)-7H-oxireno<1>benzopyran-7-one

1-[2-(4-chlorobenzoyloxy)-5-methylphenyl]-2-bromoethanone

2-(4-chlorobenzoyloxy)-5-methyl-benzoylmethyltriphenylphosphonium bromide

Refernces

• 1、 Das, Jhantu,Ghosh, Somnath. "A new synthesis of flavones and pyranoflavone by intramolecular photochemical Wittig reaction in water". supporting information; experimental part. p. 7189 - 7194. Retrieved 2012/01/05.