Diethyl(methylsulfonylmethyl)phosphonate

Base Information

• Chemical Name: Diethyl(methylsulfonylmethyl)phosphonate
• CAS No.: 40137-11-9
• Molecular Formula: C6H15O5PS
• Molecular Weight: 230.222
• Mol file: 40137-11-9.mol

Synonyms:diethyl((methylsulfonyl)methyl)phosphonate;diethyl (methylsulfonyl)methylphosphonate;diethyl (methanesulfonylmethyl)phosphonate;diethyl methylsulfonylmethylphosphonate;Methanesulfonylmethyl-phosphonic acid diethyl ester;diethyl (methylsulfonylmethyl)phosphonate;diethyl [(methylsulfonyl)methyl]phosphonate;Diethyl(methylsulfonylmethyl)phosphonate;diethyl ((methylsulfonyl)methyl)phosphonate;

Chemical Property of Diethyl(methylsulfonylmethyl)phosphonate

Chemical Property:

• Vapor Pressure: 1.91E-05mmHg at 25°C
• Melting Point: 93-95°C
• Boiling Point: 373.6±25.0 °C(Predicted)
• PSA: 87.86000
• Density: 1.241±0.06 g/cm3(Predicted)
• LogP: 2.33540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Diethylmethylsulfonylmethylphosphonate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diethyl(methylsulfonylmethyl)phosphonate

There total 10 articles about Diethyl(methylsulfonylmethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diethyl 1-(methylthio)methylphosphonate (28460-01-7) → diethyl methylsulfonylmethylphosphonate (40137-11-9)

Guidance literature:

With sodium periodate; In acetone; a) 20 deg C, 16 h, b) reflux, 3 h;

Reference yield: 86.0%

diethyl 1-(methylthio)methylphosphonate (28460-01-7) → diethyl methylsulfonylmethylphosphonate (40137-11-9) + (R)-diethyl (methylsulfinyl)methylphosphonate

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; water; (S)-[1,1']-binaphthalenyl-2,2'-diol; In tetrachloromethane; Ambient temperature;

DOI:10.1021/ja982836w

Reference yield: 85.0%

diethyl 1-(methylthio)methylphosphonate (28460-01-7) → diethyl methylsulfonylmethylphosphonate (40137-11-9) + (S)-diethyl (methylsulfinyl)methylphosphonate (220612-81-7)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; water; (R)-1,1'-Bi-2-naphthol; In tetrachloromethane; Ambient temperature;

DOI:10.1021/ja982836w

upstream raw materials:

diethyl 1-(methylthio)methylphosphonate

(Methanesulfonyl-trimethylsilanyl-methyl)-phosphonic acid diethyl ester

S,S-dimethylthioacetal of diethyl oxomethanephosphonate

(Methylsulfanyl-phenylsulfanyl-methyl)-phosphonic acid diethyl ester

Downstream raw materials:

(E)-1-fluoro-4-(2-methanesulfonyl-vinyl)-benzene

(E)-1-(4-Nitrophenyl)-2-(methylsulfonyl)-ethen

(E)-1-(2-methanesulfonyl-vinyl)-4-methoxy-benzene

(E)-1-bromo-4-(2-methanesulfonyl-vinyl)-benzene

Refernces

• 1、 -. "XPO1 protein inhibitors". Paragraph 0096-0097; 0101-0103. . Retrieved 2017/08/25.
• 2、 Otrubova, Katerina,Cravatt, Benjamin F.,Boger, Dale L.. "Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase". supporting information. p. 1079 - 1089. Retrieved 2014/03/21.