5-Pyrimidinecarbonyl chloride (7CI,9CI)

Base Information

• Chemical Name: 5-Pyrimidinecarbonyl chloride (7CI,9CI)
• CAS No.: 40929-48-4
• Molecular Formula: C5H3ClN2O
• Molecular Weight: 142.545
• Hs Code.: 2933599590
• Mol file: 40929-48-4.mol

Synonyms:pyrimidine-5-carboxylic acid chloride;5-Pyrimidinecarbonyl chloride (7CI,9CI);5-PYRIMIDINECARBONYL CHLORIDE;Pyrimidin-5-carbonsaeurechlorid;

Chemical Property of 5-Pyrimidinecarbonyl chloride (7CI,9CI)

Chemical Property:

• Vapor Pressure: 0.0646mmHg at 25°C
• Boiling Point: 230.8oC at 760 mmHg
• Flash Point: 93.4oC
• PSA: 42.85000
• Density: 1.393g/cm3
• LogP: 0.85560

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-PyrimidinecarbonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarbonyl chloride (7CI,9CI)

There total 2 articles about 5-Pyrimidinecarbonyl chloride (7CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

pyrimidine-5-carboxylic acid (4595-61-3) → pyrimidine-5-carbonyl chloride (40929-48-4)

Guidance literature:

With thionyl chloride; at 110 ℃; for 1h; Inert atmosphere;

Reference yield:

→ pyrimidine-5-carbonyl chloride (40929-48-4)

Guidance literature:

Pyrimidin-5-carbonsaeure, Thionylchlorid;

DOI:10.1021/jo01053a539

Reference yield: 88.0%

pyrimidine-5-carbonyl chloride (40929-48-4) → pyrimidine-5-carboxamide (40929-49-5)

Guidance literature:

With ammonia; In tetrahydrofuran; at 0 - 25 ℃; for 0.5h; Inert atmosphere;

upstream raw materials:

pyrimidine-5-carboxylic acid

Downstream raw materials:

N,N-dimethyl-5-pyrimidinecarboxamide

(4-bromo-2-fluorophenyl)(5-pyrimidinyl)methanone

C₁₅H₁₄N₂O₅

3-phenyl-1-(pyrimidin-5-yl)prop-2-yn-1-one

Refernces

• 1、 Zhang, Ting-jian,Tu, Shun,Zhang, Xu,Wang, Qiu-yin,Hu, Sen-sen,Zhang, Yi,Zhang, Zhen-hao,Wang, Zhao-ran,Meng, Fan-hao. "Amide-based xanthine oxidase inhibitors bearing an N-(1-alkyl-3-cyano-1H-indol-5-yl) moiety: Design, synthesis and structure-activity relationship investigation". . . Retrieved 2021/10/25.
• 2、 -. "IRAK DEGRADERS AND USES THEREOF". Paragraph 00920; 002973-002975. . Retrieved 2021/01/23.