1-Chloro-2-nonanone

Base Information

• Chemical Name: 1-Chloro-2-nonanone
• CAS No.: 41055-93-0
• Molecular Formula: C9H17ClO
• Molecular Weight: 176.686
• Hs Code.: 2914700090
• Mol file: 41055-93-0.mol

Synonyms:1-chloro-nonan-2-one;1-chloro-2-nonanone;2-Nonanone,1-chloro;1-Chlor-nonan-2-on;

Chemical Property of 1-Chloro-2-nonanone

Chemical Property:

• PSA: 17.07000
• LogP: 3.15480

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Chloro-2-nonanone

There total 18 articles about 1-Chloro-2-nonanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-chloro-N-methoxy-N-methylacetamide (67442-07-3) + n-heptylmagnesium bromide (13125-66-1) → 1-chloro-2-nonanone (41055-93-0)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 2.08333h; Inert atmosphere;

DOI:10.1039/c0ob00652a

Reference yield: 74.0%

1-Bromoheptane (629-04-9) + 2-chloro-N-methoxy-N-methylacetamide (67442-07-3) → 1-chloro-2-nonanone (41055-93-0)

Guidance literature:

1-Bromoheptane; With magnesium; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; toluene; at 0 - 25 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/c6cc06295d

Reference yield: 73.0%

1-nonyne (3452-09-3) → 1-chloro-2-nonanone (41055-93-0)

Guidance literature:

1-nonyne; With methanol; gold(III) chloride; silver(I) triflimide; In 1,4-dioxane; at 45 ℃;

With N-chloro-succinimide; In 1,4-dioxane; regioselective reaction;

DOI:10.1002/ejoc.201601416

upstream raw materials:

diazomethane

n-octanoic acid chloride

1-benzenesulfinyl-1-chloro-nonan-2-ol

n-heptyllithium

Downstream raw materials:

1-mercapto-nonan-2-one

2-Oxo-nonan-sulfonsaeure-⁽¹⁾

Acetic acid 2-oxo-nonyl ester

2-amino-4-oxo-undecanoic acid

Refernces

• 1、 -. "COMPOUNDS FOR USE AS AN ANTI-BACTERIAL OR ANTI-FUNGAL AGENT AND AS A ZINC SENSOR". Paragraph 0071; 0072; 0073. . Retrieved 2018/01/18.
• 2、 Szamosvári, Dávid,Reichle, Valentin F.,Jureschi, Monica,B?ttcher, Thomas. "Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa". supporting information. p. 13440 - 13443. Retrieved 2016/11/19.