5'-Adenylic acid, N-methyl-

Base Information

• Chemical Name: 5'-Adenylic acid, N-methyl-
• CAS No.: 4229-50-9
• Molecular Formula: C11H16N5O7P
• Molecular Weight: 361.251
• Mol file: 4229-50-9.mol

Synonyms:

Chemical Property of 5'-Adenylic acid, N-methyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-Adenylic acid, N-methyl-

There total 9 articles about 5'-Adenylic acid, N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

triethyl phosphate (78-40-0) + N6-methyladenosine (1867-73-8) → N6-methyl AMP (4229-50-9,49717-66-0) + C11H17N5O10P2 (1359697-50-9)

Guidance literature:

With water; trichlorophosphate; at 0 ℃;

DOI:10.1021/jm201127y

Reference yield:

N6-methyladenosine (1867-73-8) → N6-methyl AMP (4229-50-9,49717-66-0)

Guidance literature:

With triethyl phosphate; water; trichlorophosphate; at 0 ℃; for 2h;

DOI:10.1021/jm900728u

Reference yield:

C11H14Cl2N5O5P → N6-methyl AMP (4229-50-9,49717-66-0) + N6-Methyl-ATP (3130-39-0)

Guidance literature:

With tributyl-amine; bis(tri-n-butylammonium) pyrophosphate; In N,N-dimethyl-formamide; at -15 ℃; for 2h;

DOI:10.1080/15257771003709569

upstream raw materials:

N⁶-methyladenosine

2',3',5'-O-triacetyl-6-chloroinosine

6-N-methyladenosine 5'-acetate

triethyl phosphate

Downstream raw materials:

5'-inosine monophosphate

Refernces

• 1、 Gillerman, Irina,Fischer, Bilha. "An improved one-pot synthesis of nucleoside 5'-triphosphate analogues". experimental part. p. 245 - 256. Retrieved 2011/08/06.