5-METHYLFURAN-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-METHYLFURAN-3-CARBOXYLIC ACID
• CAS No.: 21984-93-0
• Molecular Formula: C₆H₆O₃
• Molecular Weight: 126.112
• Hs Code.: 2932190090
• Mol file: 21984-93-0.mol

Synonyms:3-Furoicacid, 5-methyl- (6CI,7CI,8CI);5-Methyl-3-furancarboxylic acid;

Chemical Property of 5-METHYLFURAN-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.0286mmHg at 25°C
• Melting Point: 119°C
• Refractive Index: 1.511
• Boiling Point: 234.8 °C at 760 mmHg
• Flash Point: 95.8 °C
• PSA: 50.44000
• Density: 1.248 g/cm³
• LogP: 1.28620
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-methylfuran-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYLFURAN-3-CARBOXYLIC ACID

There total 20 articles about 5-METHYLFURAN-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Methyl-4-<(phenylsulfonyl)methyl>furan (128496-98-0) → 5-Methyl-furan-carbonsaeure-(3) (21984-93-0)

Guidance literature:

2-Methyl-4-<(phenylsulfonyl)methyl>furan; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

With oxygen; In tetrahydrofuran; toluene; at -78 ℃;

With hydrogenchloride; In tetrahydrofuran; water; toluene; at 20 ℃; pH=1.2;

DOI:10.1021/ol200135m

Reference yield: 78.0%

2-(Phenylthio)-5-methylfuran-3-carboxylic Acid (77287-82-2) → 5-Methyl-furan-carbonsaeure-(3) (21984-93-0)

Guidance literature:

With nickel; In ethanol; for 6h; Heating;

DOI:10.1021/jo00325a009

Reference yield:

5-methyl-furan-3-carboxylic acid ethyl ester (26501-83-7) → 5-Methyl-furan-carbonsaeure-(3) (21984-93-0)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01620a031

upstream raw materials:

5-methyl-furan-3-carboxylic acid ethyl ester

2-(Phenylthio)-5-methylfuran-3-carboxylic Acid

2-methylfuran

2-methyl-5-(phenylthio)furan

Refernces

• 1、 Haines, Nathan R.,VanZanten, Aaron N.,Cuneo, Anthony A.,Miller, John R.,Andrews, William J.,Carlson, David A.,Harrington, Ryan M.,Kiefer, Adam M.,Mason, Jeremy D.,Pigza, Julie A.,Shaun Murphree. "A sulfone-based strategy for the preparation of 2,4-disubstituted furan derivatives". experimental part. p. 8131 - 8137. Retrieved 2011/11/28.