Phenyl (trifluoromethyl) sulfone

Base Information

• Chemical Name: Phenyl (trifluoromethyl) sulfone
• CAS No.: 426-58-4
• Molecular Formula: C7H5F3O2S
• Molecular Weight: 210.177
• Hs Code.: 2904909090
• Mol file: 426-58-4.mol

Synonyms:Phenyltriflate;Phenyl trifluoromethyl sulfone;trifluoromethyl phenyl sulfone;4-trifluoromethylsulfonyl benzene;

Chemical Property of Phenyl (trifluoromethyl) sulfone

Chemical Property:

• Refractive Index: 1.4620 to 1.4660
• Boiling Point: 203°C(lit.)
• PSA: 42.52000
• Density: 1.423±0.06 g/cm3(Predicted)
• LogP: 3.06090
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Phenyl Trifluoromethyl Sulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenyl (trifluoromethyl) sulfone

There total 50 articles about Phenyl (trifluoromethyl) sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

phenylsulfonyl fluoride (368-43-4) + trimethyl(trifluoromethyl)tin (754-25-6) → (trifluoromethylsulfonyl)benzene (426-58-4)

Guidance literature:

tris(dimethylamino)sulfonium trimethylsilyldifluoride; In Petroleum ether; at 25 ℃; for 1.5h;

DOI:10.1055/s-1990-27121

Reference yield: 86.0%

Langlois reagent (2926-29-6) + diphenyliodonium hexafluorophosphate (58109-40-3) → (trifluoromethylsulfonyl)benzene (426-58-4)

Guidance literature:

With copper(I) oxide; In N,N-dimethyl-formamide; at 50 ℃; for 18h; Reagent/catalyst; Solvent; Temperature; Concentration; Time; Inert atmosphere;

DOI:10.1021/jo401868x

Reference yield: 85.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + Methyl benzenesulfonate (80-18-2) → (trifluoromethylsulfonyl)benzene (426-58-4)

Guidance literature:

With cesium fluoride; In neat (no solvent); at 100 ℃; for 6h;

DOI:10.1021/jo982494c

upstream raw materials:

phenyl trifluoromethylsulfide

trifluoromethylsulfonic anhydride

benzene

phenylsulfonyl fluoride

Downstream raw materials:

4-methoxy-α-phenyl-α-(trifluoromethyl)benzenemethanol

1-([1,1’-biphenyl]-4-yl)-2,2,2-trifluoroethanol

1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene

2-Hydroxyphenyltrifluoromethylsulphone

Refernces

• 1、 Ge, Hangming,Ling, Yijing,Liu, Yafei,Lu, Long,Shen, Qilong. "Rational Design and Development of Low-Price, Scalable, Shelf-Stable and Broadly Applicable Electrophilic Sulfonium Ylide-Based Trifluoromethylating Reagents". . p. 1667 - 1682. Retrieved 2021/05/28.
• 2、 Zhou, Xiaocong,Hu, Dufen,He, Xinyi,Li, Yuanqiang,Chu, Youqun,She, Yuanbin. "Practical and efficient synthesis of aryl trifluoromethyl sulfones from arylsulfonyl chlorides with Umemoto's reagent II". supporting information. . Retrieved 2019/12/24.