Morpholin-2-one

Base Information

• Chemical Name: Morpholin-2-one
• CAS No.: 4441-15-0
• Molecular Formula: C4H7NO2
• Molecular Weight: 101.105
• Hs Code.: 2934999090
• Mol file: 4441-15-0.mol

Synonyms:FC0154;oxomorpholine;2-oxomorpholine;Morpholin-2-on;morpholinone;2-Morpholinone;

Chemical Property of Morpholin-2-one

Chemical Property:

• Vapor Pressure: 0.014mmHg at 25°C
• Melting Point: 178℃
• Boiling Point: 258.561oC at 760 mmHg
• PKA: 6.89±0.20(Predicted)
• Flash Point: 110.174oC
• PSA: 38.33000
• Density: 1.123g/cm3
• LogP: -0.53840

Purity/Quality:

99%, ^*data from raw suppliers

Morpholin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morpholin-2-one

There total 11 articles about Morpholin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-morpholinone hydrochloride → morpholin-2-one (4441-15-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h; Reagent/catalyst;

Reference yield: 88.0%

chloroacetic acid ethyl ester (105-39-5) → morpholin-2-one (4441-15-0)

Guidance literature:

With (1R,2S)-1-Amino-2-indanol; sodium hydride; In tetrahydrofuran; mineral oil; at 20 - 70 ℃; for 1.58333h; Inert atmosphere; Reflux;

Reference yield: 76.0%

4-benzyl-morpholin-2-one (5453-99-6) → morpholin-2-one (4441-15-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 3102.97 Torr;

DOI:10.1016/j.bmcl.2014.09.056

upstream raw materials:

N-(2-hydroxyethyl)iminodiacetic acid

oxirane

glycine

GlyOEt*HCl

Downstream raw materials:

5a(S),10b(R)-5a,10b-dihydro-2-(pentafluorophenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium tetrafluoroborate

4-(2-hydroxyethyl)-2-piperazinone

2-oxo-4-morpholinecarboxylic acidtert-butyl ester

4-[4-(Dibenzylamino)-3-fluorophenyl]morpholin-3-one

Refernces

• 1、 Yin, Kai-Hao,Hsieh, Yi-Han,Sulake, Rohidas S.,Wang, Su-Pei,Chao, Jui-I.,Chen, Chinpiao. "Optimization of gefitinib analogues with potent anticancer activity". supporting information. p. 5247 - 5250. Retrieved 2015/01/08.
• 2、 -. "Piperizinones as modulators of chemokine receptor activity". . . Retrieved 2008/06/13.