2-Propenoyl chloride, 3,3-diphenyl-

Base Information

• Chemical Name: 2-Propenoyl chloride, 3,3-diphenyl-
• CAS No.: 4456-79-5
• Molecular Formula: C15H11ClO
• Molecular Weight: 242.705
• Mol file: 4456-79-5.mol

Synonyms:

Chemical Property of 2-Propenoyl chloride, 3,3-diphenyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoyl chloride, 3,3-diphenyl-

There total 9 articles about 2-Propenoyl chloride, 3,3-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-diphenylacrylic acid (606-84-8) → 3,3-diphenylacryloyl chloride (4456-79-5)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide;

DOI:10.1021/jo00798a044

Reference yield:

ethyl 3,3-diphenylacrylate (17792-17-5) → 3,3-diphenylacryloyl chloride (4456-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 3M methanolic KOH / 1 h / Heating

2: (COCl₂)2 / toluene / 3 h / Heating

With potassium hydroxide; (COCl₂)2; In toluene;

DOI:10.1016/0040-4020(96)00581-9

Reference yield:

benzophenone (119-61-9) → 3,3-diphenylacryloyl chloride (4456-79-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Cooling with ice

1.2: 20 °C

2.1: sodium hydroxide / Reflux

3.1: thionyl chloride / chloroform / 12 h / 20 °C

With thionyl chloride; sodium hydride; sodium hydroxide; In tetrahydrofuran; chloroform; mineral oil;

DOI:10.3998/ark.5550190.0012.230

upstream raw materials:

1,1-Diphenylethylene

oxalyl dichloride

3,3-diphenylacrylic acid

benzophenone

Downstream raw materials:

3,3-diphenyl-acrylic acid ethylamide

3,3-diphenyl-N-(m-tolyl)acrylamide

3,3-diphenyl-acrylic acid o-toluidide

3,3-diphenyl-acrylic acid-(2-methyl-4-nitro-anilide)

Refernces

• 1、 Zhang, Ming,Kumagai, Naoya,Shibasaki, Masakatsu. "α,β-Unsaturated Amides as Dipolarophiles: Catalytic Asymmetric exo-Selective 1,3-Dipolar Cycloaddition with Nitrones". supporting information. p. 12450 - 12455. Retrieved 2017/09/18.
• 2、 Kong, Wei-Jun,Liu, Yue-Jin,Xu, Hui,Chen, Yan-Qiao,Dai, Hui-Xiong,Yu, Jin-Quan. "Pd-Catalyzed α-Selective C-H Functionalization of Olefins: En Route to 4-Imino-β-Lactams". supporting information. p. 2146 - 2149. Retrieved 2016/03/05.