3H-Indol-3-one, 2-phenyl-, oxime

Base Information

• Chemical Name: 3H-Indol-3-one, 2-phenyl-, oxime
• CAS No.: 4676-99-7
• Molecular Formula: C14H10N2O
• Molecular Weight: 222.246
• Mol file: 4676-99-7.mol

Synonyms:

Chemical Property of 3H-Indol-3-one, 2-phenyl-, oxime

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-Indol-3-one, 2-phenyl-, oxime

There total 23 articles about 3H-Indol-3-one, 2-phenyl-, oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-phenyl-indole (948-65-2) → 3-hydroxyimino-2-phenyl-3H-indole (4676-99-7)

Guidance literature:

With tert.-butylnitrite; In acetonitrile; at 80 ℃; for 0.5h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01294

Reference yield: 89.0%

2-phenyl-indole (948-65-2) → 3-Hydroxyimino-2-phenyl-3H-indole (4676-99-7)

Guidance literature:

With n-Amyl nitrite; sodium ethanolate; for 24h; Ambient temperature;

DOI:10.1055/s-1986-31622

Reference yield: 64.0%

2-phenyl-indole (948-65-2) → 2-phenyl-indol-3-one oxime (4676-99-7)

Guidance literature:

With dipotassium peroxodisulfate; sodium nitrite; In N,N-dimethyl-formamide; at 80 ℃; for 0.1h; regioselective reaction;

DOI:10.1002/adsc.201900070

upstream raw materials:

2-phenyl-indole

isopentyl nitrite

2-phenyl-3H-indol-3-one

ethanol

Downstream raw materials:

3-amino-2-phenylindole

3-amino-2-phenylindole

2-phenyl-4(3H)-quinazolinone

(E)-2-phenyl-3H-indol-3-one O-methyl oxime

Refernces

• 1、 Chen, Wei-Li,Li, Kun,Liang, Cui,Liang, Wang-Fu,Liao, Wei-Cong,Mo, Dong-Liang,Qiu, Pei-Wen,Su, Gui-Fa. "An iron(iii)-catalyzed dehydrogenative cross-coupling reaction of indoles with benzylamines to prepare 3-aminoindole derivatives". supporting information. p. 9610 - 9616. Retrieved 2021/12/09.
• 2、 Ma, Xingxing,Song, Qiuling. "Tert-Butyl Nitrite Mediated Synthesis of Fluorinated O-Alkyloxime Ether Derivatives". . p. 7375 - 7379. Retrieved 2019/09/30.