2,3,5-TRICHLOROBENZYL ALCOHOL

Base Information

• Chemical Name: 2,3,5-TRICHLOROBENZYL ALCOHOL
• CAS No.: 4681-17-8
• Molecular Formula: C7H5Cl3O
• Molecular Weight: 211.475
• Mol file: 4681-17-8.mol

Synonyms:2,3,5-Trichlor-benzylalkohol;2,3,5-trichlorobenzylalcohol;2,3,5-trichlorophenylmethanol;RARECHEM AL BD 0200;

Chemical Property of 2,3,5-TRICHLOROBENZYL ALCOHOL

Chemical Property:

• PSA: 20.23000
• LogP: 3.13910

Purity/Quality:

95% ^*data from raw suppliers

2,3,5-Trichlorobenzylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,5-TRICHLOROBENZYL ALCOHOL

There total 4 articles about 2,3,5-TRICHLOROBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,3,5-trichlorobenzaldehyde (56961-75-2) → 2,3,5-trichlorophenylmethanol (4681-17-8)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1021/jacs.0c11056

Reference yield:

2,3,5-trichlorobenzoic acid (50-73-7) → 2,3,5-trichlorophenylmethanol (4681-17-8)

Guidance literature:

With sodium hydroxide; In diethyl ether; water;

Reference yield:

1,2,4-Trichlorobenzene (120-82-1,63697-18-7) → 2,3,5-trichlorophenylmethanol (4681-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 15 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 3 h / 0 °C

With n-butyllithium; borane-THF; In tetrahydrofuran;

DOI:10.1021/jacs.0c11056

upstream raw materials:

2,3,5-trichlorobenzoic acid

2,3,5-trichlorobenzaldehyde

1,2,4-Trichlorobenzene

Downstream raw materials:

2,3,5-trichlorobenzylamine

2,3,5-trichlorophenylmethyl bromide

Refernces

• 1、 -. "Herbicidal 3-(substituted-benzyl)-1-methyl-6-trifluoromethyluracils". . . Retrieved 2008/06/13.
• 2、 -. "Pharmacologically active CNS compound". . . Retrieved 2008/06/13.