BENZOFURAN-3-CARBALDEHYDE

Base Information

• Chemical Name: BENZOFURAN-3-CARBALDEHYDE
• CAS No.: 4687-25-6
• Molecular Formula: C9H6O2
• Molecular Weight: 146.145
• Hs Code.: 2932999099
• Mol file: 4687-25-6.mol

Synonyms:1-benzofuran-3-carbaldehyde;benzofurane-3-carbaldehyde;BENZOFURAN-3-CARBOXALDEHYDE;benzofuran-3-carbaldehyde;benzofurane 3-carboxaldehyde;

Chemical Property of BENZOFURAN-3-CARBALDEHYDE

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 0.02mmHg at 25°C
• Melting Point: 39℃ (ligroine )
• Refractive Index: 1.652
• Boiling Point: 251.549oC at 760 mmHg
• Flash Point: 110.192oC
• PSA: 30.21000
• Density: 1.238g/cm3
• LogP: 2.24530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzofuran-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOFURAN-3-CARBALDEHYDE

There total 19 articles about BENZOFURAN-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

3-methyl-benzofuran (21535-97-7) → 1-benzofuran-3-carbaldehyde (4687-25-6)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 75 ℃; for 92h;

DOI:10.1039/b710935k

Reference yield: 88.0%

3-methyl-benzofuran (21535-97-7) → 3-hydroxymethylbenzofuran (4687-23-4) + 1-benzofuran-3-carbaldehyde (4687-25-6)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 105 ℃; for 48h;

DOI:10.1016/j.bmc.2007.05.072

Reference yield: 85.0%

2,2'-(benzofuran-3-ylmethylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) → 1-benzofuran-3-carbaldehyde (4687-25-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/jacs.0c03197

upstream raw materials:

2-(3-benzofuranyl)acetic acid

3-formylbenzofuran-2-carboxylic acid

3-hydroxymethylbenzofuran

3-methyl-benzofuran

Downstream raw materials:

rac-1-(benzofuran-3-yl)ethan-1-ol

benzofurane-3-carboxylic acid

3-hydroxymethylbenzofuran

benzofuran-3-carboxaldehyde oxime

Refernces

• 1、 Kamila, Sukanta,Ankati, Haribabu,Biehl, Edward R.. "Microwave assisted synthesis of novel functionalized hydantoin derivatives and their conversion to 5-(Z) arylidene-4H-imidazoles". . p. 5527 - 5537. Retrieved 2011.
• 2、 Hashmi, A. Stephen K.,Rominger, Frank,Si, Xiaojia,Zhang, Lumin. "Visible-Light-Induced Radical Carbo-Cyclization/ gem-Diborylation through Triplet Energy Transfer between a Gold Catalyst and Aryl Iodides". . p. 10485 - 10493. Retrieved 2020/07/03.
• 3、 -. "Mercapto-amide boronic acid derivative and application thereof as MBL (metal beta-lactamase) and/or SBL (serine beta-lactamase) inhibitor". Paragraph 0090; 0091; 0096; 0097. . Retrieved 2019/09/14.