4-Methyl-tetrahydro-2H-thiopyran

Base Information

• Chemical Name: 4-Methyl-tetrahydro-2H-thiopyran
• CAS No.: 5161-17-1
• Molecular Formula: C6H12S
• Molecular Weight: 116.22
• Hs Code.: 2934999090
• Mol file: 5161-17-1.mol

Synonyms:2H-Thiopyran, tetrahydro-4-methyl-;2H-Thiopyran,tetrahydro-4-methyl;Thiopyran,tetrahydro-4-methyl;

Chemical Property of 4-Methyl-tetrahydro-2H-thiopyran

Chemical Property:

• Vapor Pressure: 3.46mmHg at 25°C
• Melting Point: -28.1°C
• Refractive Index: 1.4899
• Boiling Point: 158°C at 760 mmHg
• Flash Point: 42.7°C
• PSA: 25.30000
• Density: 0.922g/cm³
• LogP: 2.14950

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methyl-tetrahydro-2H-thiopyran

There total 11 articles about 4-Methyl-tetrahydro-2H-thiopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-methyl-1,5-dibromopentane (4457-72-1) → tetrahydro-4-methyl-2H-thiopyran (5161-17-1)

Guidance literature:

With sodiumsulfide nonahydrate; at 170 ℃; for 7h;

DOI:10.1080/17415993.2019.1620230

Reference yield: 78.0%

3-methyl-1,5-pentanediyl dimesylate (500862-51-1) → tetrahydro-4-methyl-2H-thiopyran (5161-17-1)

Guidance literature:

With sodium sulfide; In ethanol;

DOI:10.1021/jo0497306

Reference yield:

3-methylpentane-1,5-diol (4457-71-0) → tetrahydro-4-methyl-2H-thiopyran (5161-17-1)

Guidance literature:

With aluminium oxide-chromium oxide; hydrogen sulfide; at 265 ℃;

upstream raw materials:

3-methyl-1,5-dibromopentane

3-methylpentane-1,5-diol

1-phenylselenyl-2-thia-5-methyl-5-hexene

(3-methyl-but-3-enylsulfanyl)-acetic acid 2-thioxo-2H-pyridin-1-yl ester

Downstream raw materials:

4-methylthiane 1,1-dioxide

trans-tetrahydro-4-methyl-2H-thiopyran 1-oxide

cis-tetrahydro-4-methyl-2H-thiopyran 1-oxide

Refernces

• 1、 Basche, Luis,Jung, Sebastian T.,Luy, Burkhard,Podlech, Joachim,Reinsperger, Tony. "Stereoelectronic Effects: Perlin Effects in Thiane-Derived Compounds". . . Retrieved 2020/04/15.
• 2、 Della, Ernest W.,Graney, Sean D.. "The regiochemistry of cyclization of α-sulfenyl-, α-sulfinyl-, and α-sulfonyl-5-hexenyl radicals: Procedures leading to regioselective syntheses of cyclic sulfones and sulfoxides". . p. 3824 - 3835. Retrieved 2007/10/03.