Methyl 4-(2-hydroxyethoxy)benzoate

Base Information

• Chemical Name: Methyl 4-(2-hydroxyethoxy)benzoate
• CAS No.: 3204-73-7
• Molecular Formula: C10H12 O4
• Molecular Weight: 196.203
• Hs Code.: 2918990090
• European Community (EC) Number: 221-708-8
• UNII: 9XG5332XHD
• DSSTox Substance ID: DTXSID2062903
• Nikkaji Number: J62.061K
• Wikidata: Q81990340
• Mol file: 3204-73-7.mol

Synonyms:Methyl 4-(2-hydroxyethoxy)benzoate;3204-73-7;4-(2-Hydroxyethoxy)benzoic Acid Methyl Ester;Benzoic acid, 4-(2-hydroxyethoxy)-, methyl ester;Methyl p-(2-hydroxyethoxy)benzoate;9XG5332XHD;EINECS 221-708-8;MFCD00075872;AI3-23241;Methyl4-(2-Hydroxyethoxy)benzoate;UNII-9XG5332XHD;SCHEMBL64651;DTXSID2062903;methyl 4-(2-hydroxyethoxyl)benzoate;AKOS000313899;Methyl 4-(2-hydroxyethoxy)benzoate #;CS-W010601;AS-47798;SY052493;FT-0693552;H0820;F16170;4-(2-hydroxy-ethoxy)-benzoic acid methyl ester;EN300-7403291;METHYL 4-(.BETA.-HYDROXYETHOXY)BENZOATE;Methyl 4-(2-hydroxyethoxy)benzoate, AldrichCPR;Z335703518;25232-94-4

Chemical Property of Methyl 4-(2-hydroxyethoxy)benzoate

Chemical Property:

• Vapor Pressure: 4.38E-05mmHg at 25°C
• Melting Point: 66°C
• Boiling Point: 336.5°C at 760 mmHg
• Flash Point: 132.6°C
• PSA: 55.76000
• Density: 1.186g/cm³
• LogP: 0.84430
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 196.07355886
• Heavy Atom Count: 14
• Complexity: 173

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-Hydroxyethoxy)BenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-52-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=CC=C(C=C1)OCCO

Technology Process of Methyl 4-(2-hydroxyethoxy)benzoate

There total 9 articles about Methyl 4-(2-hydroxyethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[1,3]-dioxolan-2-one (96-49-1) + methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-(2-hydroxyethoxy)benzoic acid methyl ester (3204-73-7)

Guidance literature:

With sodium iodide; In diethylene glycol dimethyl ether; at 140 - 160 ℃; for 18h;

DOI:10.1039/c9sc02557j

Reference yield: 93.3%

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) + 2-bromoethanol (540-51-2) → 4-(2-hydroxyethoxy)benzoic acid methyl ester (3204-73-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃;

Reference yield: 93.0%

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) + 2-chloro-ethanol (107-07-3) → 4-(2-hydroxyethoxy)benzoic acid methyl ester (3204-73-7)

Guidance literature:

With potassium carbonate; potassium iodide; In cyclohexanone; for 24h; Heating;

DOI:10.1016/j.tet.2004.06.019

upstream raw materials:

methyl 4-hydroxylbenzoate

2-chloro-ethanol

4-hydroxy-benzoic acid

sodium methylparaben

Downstream raw materials:

(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)methanol

Refernces

• 1、 Johann, Tobias,Keth, Jennifer,Bros, Matthias,Frey, Holger. "A general concept for the introduction of hydroxamic acids into polymers". . p. 7009 - 7022. Retrieved 2019.
• 2、 Nandy, Sneha,Ghatak, Avishek,Das, Asit Kumar,Bhar, Sanjay. "Chemoselective and Metal-Free Synthesis of Aryl Esters from the Corresponding Benzylic Alcohols in Aqueous Medium Using TBHP/TBAI as an Efficient Catalytic System". . p. 2208 - 2212. Retrieved 2018/10/02.