Gly-Gly benzyl ester p-toluenesulfonate salt

Base Information

• Chemical Name: Gly-Gly benzyl ester p-toluenesulfonate salt
• CAS No.: 1738-82-5
• Molecular Formula: C18H22N2O6S
• Molecular Weight: 394.448
• Hs Code.: 2924299090
• Mol file: 1738-82-5.mol

Synonyms:benzyl 2-[(2-aminoacetyl)amino]acetate; 4-methylbenzenesulfonic acid;

Chemical Property of Gly-Gly benzyl ester p-toluenesulfonate salt

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 7.26E-07mmHg at 25°C
• Melting Point: 157-159oC
• Boiling Point: 408 °C at 760 mmHg
• Flash Point: 200.5 °C
• PSA: 144.17000
• LogP: 3.21840
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzyl2-(2-Aminoacetamido)Acetate4-Methylbenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of Gly-Gly benzyl ester p-toluenesulfonate salt

There total 1 articles about Gly-Gly benzyl ester p-toluenesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

glycylglycine (556-50-3) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → glycylglycine benzyl ester p-toluene sulfonate salt (1738-82-5)

Guidance literature:

In toluene; for 8h; Heating;

DOI:10.1021/ja0558894

Reference yield: 94.0%

glycylglycine benzyl ester p-toluene sulfonate salt (1738-82-5) + dioctadecylcarbamoylmethoxyacetic acid (154269-28-0) → [2-(2-dioctadecylcarbamoylmethoxy-acetylamino)-acetylamino]-acetic acid benzyl ester (562076-70-4)

Guidance literature:

dioctadecylcarbamoylmethoxyacetic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

glycylglycine benzyl ester p-toluene sulfonate salt; With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/ja0558894

Reference yield: 93.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + glycylglycine benzyl ester p-toluene sulfonate salt (1738-82-5) → Boc-PGG-OCH2Ph (31953-81-8)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 49h;

DOI:10.1021/ja0558894

upstream raw materials:

glycylglycine

toluene-4-sulfonic acid

benzyl alcohol

Downstream raw materials:

N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester

Boc-PGG-OCH₂Ph

N-Benzyloxycarbonyl-(RS)-(5-benzyloxy-2-pyridyl)glycyl-glycylglycinbenzylester

succinyl-Gly-Gly-OBzl

Refernces

• 1、 Pajewski, Robert,Ferdani, Riccardo,Pajewska, Jolanta,Li, Ruiqiong,Gokel, George W.. "Cation dependence of chloride ion complexation by open-chained receptor molecules in chloroform solution". . p. 18281 - 18295. Retrieved 2007/10/03.