2-Aminoimidazole

Base Information

• Chemical Name: 2-Aminoimidazole
• CAS No.: 7720-39-0
• Molecular Formula: C3H5N3
• Molecular Weight: 83.0928
• Hs Code.: 2933290090
• European Community (EC) Number: 231-751-4
• DSSTox Substance ID: DTXSID60227953
• Nikkaji Number: J252F
• Wikidata: Q27452839
• Metabolomics Workbench ID: 130051
• ChEMBL ID: CHEMBL291627
• Mol file: 7720-39-0.mol

Synonyms:Imidazole,2-amino- (7CI,8CI);2-Amino-1H-imidazole;2-Imidazolamine;

Chemical Property of 2-Aminoimidazole

Chemical Property:

• Vapor Pressure: 0.000506mmHg at 25°C
• Refractive Index: 1.647
• Boiling Point: 313.1 °C at 760 mmHg
• PKA: 15.06±0.10(Predicted)
• Flash Point: 168.9 °C
• PSA: 54.70000
• Density: 1.313 g/cm³
• LogP: 0.57310
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 83.048347172
• Heavy Atom Count: 6
• Complexity: 45.3

Purity/Quality:

1H-Imidazol-2-amine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(N1)N

Technology Process of 2-Aminoimidazole

There total 26 articles about 2-Aminoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-aminoimidazolesulfate (42383-61-9) → 1H-imidazol-2-amine (7720-39-0)

Guidance literature:

With sodium hydrogencarbonate; In water; Inert atmosphere;

DOI:10.1002/hlca.201300308

Reference yield: 98.0%

2-azido-1H-imidazole → 1H-imidazol-2-amine (7720-39-0)

Guidance literature:

With hydrogen; In ethanol; at 20 ℃;

DOI:10.1002/ejoc.201000625

Reference yield: 91.0%

2-nitro-1H-imidazole (527-73-1) → 1H-imidazol-2-amine (7720-39-0)

Guidance literature:

With triethylamine; In water; at 80 ℃; for 4h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1039/c4ra01333f

upstream raw materials:

2-nitro-1H-imidazole

2-aminoimidazole hemisulfate

hydrogenchloride

2-(p-tolylazo)imidazole

Downstream raw materials:

sulfanilic acid-(1H-imidazol-2-ylamide)

5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

(1S,2S)-2-Phenoxymethyl-cyclopropanecarboxylic acid (1H-imidazol-2-yl)-amide

(+/-)-hymenin

Refernces

• 1、 Adam, Zachary R.,Ali, Sarfaraz,Cleaves, H. James,Fahrenbach, Albert C.,Tran, Quoc Phuong,Yi, Ruiqin,Yoda, Isao. "A continuous reaction network that produces RNA precursors". . p. 13267 - 13274. Retrieved 2020.
• 2、 Assun??o, Elvis L. F.,Carvalho, Diego B.,das Neves, Amarith R.,Kawasoko Shiguemotto, Cristiane Y.,Portapilla, Gisele B.,de Albuquerque, Sergio,Baroni, Adriano C. M.. "Synthesis and Antitrypanosomal Activity of 1,4-Disubstituted Triazole Compounds Based on a 2-Nitroimidazole Scaffold: a Structure-Activity Relationship Study". . p. 2019 - 2028. Retrieved 2020/09/21.