8-Quinolinecarboxylic acid, 2-phenyl-

Base Information

• Chemical Name: 8-Quinolinecarboxylic acid, 2-phenyl-
• CAS No.: 5093-81-2
• Molecular Formula: C16H11NO2
• Molecular Weight: 249.269
• Mol file: 5093-81-2.mol

Synonyms:

Chemical Property of 8-Quinolinecarboxylic acid, 2-phenyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Quinolinecarboxylic acid, 2-phenyl-

There total 13 articles about 8-Quinolinecarboxylic acid, 2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

8-methyl-2-phenylquinoline (5353-90-2) → 2-phenylquinoline-8-carboxylic acid (5093-81-2)

Guidance literature:

With selenium(IV) oxide; a) 180 to 190 deg C, b) 280 to 290 deg C, 2 min;

DOI:10.1021/jm00122a018

Reference yield: 15.0%

→ 2-phenylquinoline-8-carboxylic acid (5093-81-2)

Guidance literature:

Reference yield:

(E)-3-phenylpropenal (14371-10-9) + conc. H2 SO4 + H3 AsO4 + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-phenylquinoline-8-carboxylic acid (5093-81-2)

Guidance literature:

With acetic acid; In methanol; dichloromethane; water;

upstream raw materials:

8-methyl-2-phenylquinoline

2-phenyl-4(1H)-quinolone-8-carboxylic acid

2-phenyl-8-methylquinoline-4-carboxylic acid

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

2-phenyl-8-(1-methylbenzimidazol-2-yl)quinoline

2-phenyl-8-(1-ethylbenzimidazol-2-yl)quinoline

2-phenyl-8-(1-isopropylbenzimidazol-2-yl)quinoline

8-(1H-benzimidazol-2-yl)-2-phenylquinoline

Refernces

• 1、 -. "Substituted quinoline derivatives and pharmaceutical compositions thereof". . . Retrieved 2008/06/13.
• 2、 Atwell, Graham, J.,Bos, Claudia D.,Baguley, Bruce C.,Denny, William A.. "Potential Antitumor Agents. 56. "Minimal" DNA-Intercalating Ligands as Antitumor Drugs: Phenylquinoline-8-carboxamides". . p. 1048 - 1052. Retrieved 2007/10/02.