1-phenyl-2-(quinolin-2-yl)ethanone

Base Information

• Chemical Name: 1-phenyl-2-(quinolin-2-yl)ethanone
• CAS No.: 1531-38-0
• Molecular Formula: C17H13 N O
• Molecular Weight: 247.296
• Mol file: 1531-38-0.mol

Synonyms:Acetophenone,2-(2-quinolyl)- (6CI,7CI,8CI); 2-(2-Quinolyl)acetophenone;2-(Benzoylmethyl)quinoline; 2-Phenacylquinoline; NSC 3329; a-(2-Quinolinyl)acetophenone

Chemical Property of 1-phenyl-2-(quinolin-2-yl)ethanone

Chemical Property:

• Vapor Pressure: 5.95E-07mmHg at 25°C
• Boiling Point: 410.6°Cat760mmHg
• Flash Point: 208.4°C
• Density: 1.183g/cm³

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenyl-2-(quinolin-2-yl)ethanone

There total 17 articles about 1-phenyl-2-(quinolin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Chloroquinoline (612-62-4) + acetophenone (98-86-2) → 2-benzoylmethylquinoline (1531-38-0)

Guidance literature:

With sodium amalgam; potassium tert-butylate; ammonia; for 2h;

DOI:10.1016/S0040-4020(01)81279-5

Reference yield: 81.0%

2-phenylethynylquinoline (70437-00-2) → 2-benzoylmethylquinoline (1531-38-0)

Guidance literature:

With water; sulfuric acid; mercury(II) sulfate; In acetone; for 36h;

DOI:10.1248/cpb.29.3554

Reference yield: 78.0%

2-methylquinoline (91-63-4) + benzoic acid ethyl ester (93-89-0,99341-95-4) → 2-benzoylmethylquinoline (1531-38-0)

Guidance literature:

2-methylquinoline; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 2.16667h; Inert atmosphere;

benzoic acid ethyl ester; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 12.3333h; Inert atmosphere;

DOI:10.1055/s-0030-1259905

upstream raw materials:

2-methylquinoline

benzoic acid ethyl ester

2-(α,β-dibromo-phenethyl)-quinoline

benzoic acid methyl ester

Downstream raw materials:

2-tribromomethyl-quinoline

1,3-Diphenyl-2-(quinoline-2-yl)propan-1-one

(Z)-1,2-dihydro-2-benzoylmethylenequinoline

syn-(E)-2-(2-Chinolyl)-1-phenylethanonoxim

Refernces

• 1、 Nazareno, Monica A.,Rossi, Roberto A.. "SmI2 Catalyzed SRN1 Reactions of Haloarenes with Acetophenone Enolate Ions in DMSO". . p. 5185 - 5188. Retrieved 1994.
• 2、 -. "A 1:1 type enol-pyruvyl quinazine metal complex and its synthetic method and application". Paragraph 0017; 0018. . Retrieved 2017/02/23.
• 3、 Graser, Markus,Kopacka, Holger,Wurst, Klaus,Müller, Thomas,Bildstein, Benno. "Structurally diverse pyridyl or quinolyl enolato/enamido metal complexes of Li, Zr, Fe, Co, Ni, Cu and Zn". . p. 38 - 49. Retrieved 2013/08/14.