6-Cyano-2-naphthoic acid

Base Information

• Chemical Name: 6-Cyano-2-naphthoic acid
• CAS No.: 5159-60-4
• Molecular Formula: C12H7NO2
• Molecular Weight: 197.193
• Hs Code.: 2926909090
• Mol file: 5159-60-4.mol

Synonyms:2-Naphthalenecarboxylic acid,6-cyano;

Chemical Property of 6-Cyano-2-naphthoic acid

Chemical Property:

• PSA: 61.09000
• LogP: 2.40968
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

6-Cyano-2-naphthoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Cyano-2-naphthoic acid

There total 13 articles about 6-Cyano-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-cyano-naphthalene-2-carboxylic acid methyl ester (5088-91-5) → 6-cyano-naphthalene-2-carboxylic acid (5159-60-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 1.5h;

DOI:10.1021/jm0300072

Reference yield: 86.0%

aqueous LiOH + 6-cyano-naphthalene-2-carboxylic acid methyl ester (5088-91-5) → 6-cyano-naphthalene-2-carboxylic acid (5159-60-4)

Guidance literature:

In tetrahydrofuran; dichloromethane;

Reference yield:

LiOH·H2O + 6-cyano-naphthalene-2-carboxylic acid methyl ester (5088-91-5) → 6-cyano-naphthalene-2-carboxylic acid (5159-60-4)

Guidance literature:

In tetrahydrofuran-water; water;

upstream raw materials:

naphthalene-2,6-dicarbonitrile

6-cyano-naphthalene-2-carboxylic acid methyl ester

naphthalene-2,6-dicarboxylic acid monomethyl ester

6-(Chlorocarbonyl)-2-naphthalenecarboxylic acid,methyl ester

Downstream raw materials:

6-(N-phenylcarbamyl)-2-naphthalenecarbonitrile

6-[N-(4-ethylphenyl)carbamyl]-2-naphthalenecarbonitrile

6-cyano-2-naphthol

6-cyano-N-(3'-methoxybiphenyl-4-yl)-2-naphthamide

Refernces

• 1、 Venkatraj, Muthusamy,Messagie, Jonas,Joossens, Jurgen,Lambeir, Anne-Marie,Haemers, Achiel,Van Der Veken, Pieter,Augustyns, Koen. "Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)". scheme or table. p. 1557 - 1568. Retrieved 2012/04/17.
• 2、 -. "Urokinase inhibitors". . . Retrieved 2008/06/13.