Benzene, 1,2,3-trimethoxy-4-(1E)-1-propenyl-

Base Information

• Chemical Name: Benzene, 1,2,3-trimethoxy-4-(1E)-1-propenyl-
• CAS No.: 5273-90-5
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol file: 5273-90-5.mol

Synonyms:1,2,3-Trimethoxy-4-((E)-propenyl)-benzene;1,2,3-trimethoxy-4-propenylbenzene;trans-2,3,4-Trimethoxy-1-propenyl-benzol;

Chemical Property of Benzene, 1,2,3-trimethoxy-4-(1E)-1-propenyl-

Chemical Property:

• Melting Point: 32 - 34 °C
• PSA: 27.69000
• LogP: 2.74550

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1,2,3-trimethoxy-4-(1E)-1-propenyl-

There total 7 articles about Benzene, 1,2,3-trimethoxy-4-(1E)-1-propenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(2,3,4-trimethoxyphenyl)-1-propanol (54440-47-0) → (E)-1,2,3-trimethoxy-4-(prop-1-en-1-yl)benzene (5273-90-5)

Guidance literature:

With 1-hexyl-3-methyl-1-imidazolium bromide; at 140 ℃; for 0.1h; chemoselective reaction; Microwave irradiation; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1002/ejoc.200800657

Reference yield: 84.0%

ethyltriphenylphosphonium bromide (1530-32-1) + 2,3,4-trimethoxybenzaldehyde (2103-57-3) → (E)-1,2,3-trimethoxy-4-(prop-1-en-1-yl)benzene (5273-90-5)

Guidance literature:

ethyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

2,3,4-trimethoxybenzaldehyde; In tetrahydrofuran; at -78 - 25 ℃; for 3.83333h; Inert atmosphere;

With dichloro bis(acetonitrile) palladium(II); In chloroform; at 25 ℃; for 72h;

DOI:10.3998/ark.5550190.0011.206

Reference yield:

2,3,4-trimethoxybenzaldehyde (2103-57-3) → (E)-1,2,3-trimethoxy-4-(prop-1-en-1-yl)benzene (5273-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium / diethyl ether / 2 h

1.2: 88 percent / diethyl ether; toluene / 20 °C

2.1: 71 percent / silica gel / dioxane / 0.05 h / microwave irradiation

With silica gel; magnesium; In 1,4-dioxane; diethyl ether; 1.2: Grignard reaction;

DOI:10.1246/bcsj.77.2231

upstream raw materials:

1-Allyl-2,3,4-trimethoxybenzene

1-(2,3,4-trimethoxyphenyl)-1-propanol

2,3,4-trimethoxybenzaldehyde

2,3-dimethoxyphenol

Refernces

• 1、 Green, Ivan R.,October, Natasha. "Role of the methoxy group in product formation via TiCl 4 promoted 4-phenyldioxolane isomerizations". experimental part. p. 71 - 96. Retrieved 2010/07/20.
• 2、 Sharma, Anuj,Joshi, Bhupendra P.,Sinha, Arun K.. "An effective system to synthesize hypolipidemic active α-asarone and related methoxylated (E)-arylalkenes". . p. 2231 - 2235. Retrieved 2007/10/03.