Glycine, N-(phenylmethyl)-, methyl ester

Base Information

• Chemical Name: Glycine, N-(phenylmethyl)-, methyl ester
• CAS No.: 53386-64-4
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2922499990
• Mol file: 53386-64-4.mol

Synonyms:GLYCINE, N-(PHENYLMETHYL)-, METHYL ESTER;

Chemical Property of Glycine, N-(phenylmethyl)-, methyl ester

Chemical Property:

• Boiling Point: 130-132 °C(Press: 6 Torr)
• PKA: 6.46±0.20(Predicted)
• PSA: 38.33000
• Density: 1.069±0.06 g/cm3(Predicted)
• LogP: 1.34010
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95% ^*data from raw suppliers

Methyl2-(benzylamino)acetate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-(phenylmethyl)-, methyl ester

There total 24 articles about Glycine, N-(phenylmethyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + N-benzylglycine (17136-36-6) → methyl 2-(benzylamino)acetate (53386-64-4)

Guidance literature:

With thionyl chloride; In methanol; at 0 ℃; for 18h;

DOI:10.1016/j.ejmech.2014.12.005

Reference yield: 99.0%

methyl 2-(benzylideneamino)acetate (66646-88-6) → methyl 2-(benzylamino)acetate (53386-64-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at -5 ℃; for 2h;

Reference yield: 92.0%

bromoacetic acid methyl ester (96-32-2) + benzylamine (100-46-9) → methyl 2-(benzylamino)acetate (53386-64-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/jlcr.507

upstream raw materials:

methyl chloroacetate

benzylamine

methyl hippurate

1-benzyl-3,3-dimethyl-aziridine-2-carboxylic acid methyl ester

Downstream raw materials:

[(2-Acetylamino-6-chloro-benzyl)-benzyl-amino]-acetic acid

3-benzyloxazolidine-4-carboxylate de methyle

N-(1,1-diphenylmethyl) glycine methyl ester

N-benzyl-N-<7-(trimethylsilyl)-5-oxohept-6-yn-1-oyl>glycine methyl ester

Refernces

• 1、 Guo, Bin,Li, Qingeng,Shen, Yi,Xiu, Jingya. "Synthesis and biological activity evaluation of azacycloheptane sulfonamide derivatives as potential orexin receptor antagonists". . p. 30683 - 30691. Retrieved 2020/09/11.
• 2、 Thurow, Samuel,Lenardo, Eder J.,Just-Baringo, Xavier,Procter, David J.. "Reduction of selenoamides to amines using SmI2-H2O". . p. 50 - 53. Retrieved 2017/11/28.