Phenylpropanolamine hydrochloride

Base Information

• Chemical Name: Phenylpropanolamine hydrochloride
• CAS No.: 53631-70-2
• Molecular Formula: C9H13NO.ClH
• Molecular Weight: 187.669
• European Community (EC) Number: 205-826-7
• UN Number: 2811
• DSSTox Substance ID: DTXSID6027185
• NCI Thesaurus Code: C66379
• ChEMBL ID: CHEMBL1200695
• Mol file: 53631-70-2.mol

Synonyms:Dexatrim;Hydrochloride, Phenylpropanolamine;Norephedrine;Phenylpropanolamine;Phenylpropanolamine Hydrochloride;Prolamine;Propagest;Triaminic DM

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Phenylpropanolamine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 187.0763918
• Heavy Atom Count: 12
• Complexity: 110
• Transport DOT Label: Poison

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)O)N.Cl

Technology Process of Phenylpropanolamine hydrochloride

There total 10 articles about Phenylpropanolamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

threo-1-benzoyloxy-1-phenyl-2-propylammonium chloride (38222-78-5) → threo-1-phenyl-1-hydroxy-2-propylammonium chloride (154-41-6,1485-15-0,2153-98-2,3198-15-0,4345-16-8,40626-29-7,53631-70-2,53643-20-2,54705-32-7)

Guidance literature:

With hydrogenchloride; for 30h; Heating;

Reference yield: 74.0%

trans-2,5-diphenyl-4-methyl-1,3-oxazoline (38222-77-4) → threo-1-phenyl-1-hydroxy-2-propylammonium chloride (154-41-6,1485-15-0,2153-98-2,3198-15-0,4345-16-8,40626-29-7,53631-70-2,53643-20-2,54705-32-7)

Guidance literature:

With hydrogenchloride; for 30h; Heating;

Reference yield:

2-nitro-1-phenylpropan-1-ol (26251-08-1,26251-09-2,38316-08-4,38316-09-5,6343-57-3) → u-2-amino-1-phenylpropan-1-ol (14838-15-4,58550-13-3,757124-50-8) + (+/-)-Norpseudoephedrine hydrochloride (154-41-6,1485-15-0,2153-98-2,3198-15-0,4345-16-8,40626-29-7,53631-70-2,53643-20-2,54705-32-7)

Guidance literature:

With sulfuric acid; iron; Trennung der Isomeren erfolgt durch fraktionierte Krystallization aus absol.Alkohol;

upstream raw materials:

2-nitro-1-phenylpropan-1-ol

(1RS,2RS)-2-dibenzylamino-1-phenyl-propan-1-ol; hydrochloride

benzaldehyde

(RS)-mandelonitrile

Downstream raw materials:

(1S,2R)-(+)-norphedrine

(1R,2S)-norephedrine

(1R,2S)-(-)-norephedrine hydrochloride

threo-1-chloro-1-phenyl-2-propylammonium chloride

Refernces

• 1、 Kniezo, Ladislav,Kristian, Pavol,Budesinsky, Milos,Havrilova, Katarina. "STEREOCHEMICAL COURSE OF THE REACTION OF 2-HALOETHYL ISOTHIOCYANATES WITH NUCLEOPHILES. sTEREOSPECIFIC ROUTE TO 4,5-DISUBSTITUTED Δ2-THIAZOLINES AND THIAZOLIDINE-2-THIONES". . p. 717 - 728. Retrieved 2007/10/02.