N-(4-methylphenyl)-1-pyridin-2-ylmethanimine

Base Information

• Chemical Name: N-(4-methylphenyl)-1-pyridin-2-ylmethanimine
• CAS No.: 7471-13-8
• Molecular Formula: C13H12N2
• Molecular Weight: 196.252
• NSC Number: 403548
• DSSTox Substance ID: DTXSID80323305
• Nikkaji Number: J960.335B,J2.906.836D
• Mol file: 7471-13-8.mol

Synonyms:N-(4-methylphenyl)-1-pyridin-2-ylmethanimine;7471-13-8;NSC403548;N-p-Tolyl-2-pyridinemethanimine;SCHEMBL17552020;DTXSID80323305;NSC-403548;4-methyl-N-(pyridin-2-ylmethylidene)aniline;N-[(E)-2-Pyridylmethylene]-4-methylaniline

Chemical Property of N-(4-methylphenyl)-1-pyridin-2-ylmethanimine

Chemical Property:

• Vapor Pressure: 8.09E-05mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 351.9 °C at 760 mmHg
• Flash Point: 166.6 °C
• Density: 1.01 g/cm³
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 196.100048391
• Heavy Atom Count: 15
• Complexity: 205

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N=CC2=CC=CC=N2

Technology Process of N-(4-methylphenyl)-1-pyridin-2-ylmethanimine

There total 25 articles about N-(4-methylphenyl)-1-pyridin-2-ylmethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

pyridine-2-carbaldehyde (1121-60-4) + p-toluidine (106-49-0,12221-03-3) → N-(pyrid-2-ylmethylene)-p-tolylamine (7471-13-8)

Guidance literature:

In toluene; at 20 ℃; for 16h;

DOI:10.1016/j.jorganchem.2021.122187

Reference yield: 88.0%

4-methyl-N-((pyridine-2-yl)methyl)benzeneamine (4334-26-3) → N-(pyrid-2-ylmethylene)-p-tolylamine (7471-13-8)

Guidance literature:

With N,N-bis(pyridin-2-ylmethyl)benzenamine; oxygen; copper(II) bis(trifluoromethanesulfonate); triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; under 760.051 Torr; Sealed tube;

DOI:10.1039/c7ob02192e

Reference yield:

C20H21N3 → N-(pyrid-2-ylmethylene)-p-tolylamine (7471-13-8) + benzylamine (100-46-9)

Guidance literature:

With methanesulfonic acid; In [D₃]acetonitrile; at 20 ℃; for 24h; Equilibrium constant; Molecular sieve;

DOI:10.1021/jacs.5b11361

upstream raw materials:

pyridine-2-carbaldehyde

p-toluidine

tetrabutyl-ammonium chloride

zinc trifluoromethanesulfonate

Downstream raw materials:

4-N-p-methylphenylamino-4-[α-pyridyl]-1-butene

Pt(N-4-tolylpyridine-2-aldimine)Cl₂

(C₅H₄NCHNC₆H₄CH₃)Fe₂(CO)6

ReCl₃(P(C₆H₅)3)(C₁₃H₁₂N₂)

Refernces

• 1、 Gichumbi, Joel M.,Friedrich, Holger B.,Omondi, Bernard,Chenia, Hafizah Y.. "Synthesis, characterization, and antimicrobial studies of half-sandwich η6-toluene ruthenium complexes with N,N′-bidentate ligands". . p. 1833 - 1847. Retrieved 2020/08/05.
• 2、 Ramos, Thiago S.,Luz, Diego M.,Nascimento, Rebecca D.,Silva, Andressa K.,Li?o, Luciano M.,Miranda, Victor M.,Deflon, Victor M.,de Araujo, Márcio P.,Ueno, Leonardo T.,Machado, Francisco B.C.,Dinelli, Luís R.,Bogado, André L.. "Ruthenium-cymene containing pyridine-derived aldiimine ligands: Synthesis, characterization and application in the transfer hydrogenation of aryl ketones and kinetics studies". . p. 51 - 65. Retrieved 2019/05/10.