1,2-BENZENEDICARBOXYLIC ACID,4-CHLORO-,1,2-DIMETHYL ESTER

Base Information

• Chemical Name: 1,2-BENZENEDICARBOXYLIC ACID,4-CHLORO-,1,2-DIMETHYL ESTER
• CAS No.: 58138-38-8
• Molecular Formula: C10H9ClO4
• Molecular Weight: 228.632
• Mol file: 58138-38-8.mol

Synonyms:dimethyl-4-chlorophthalate;4-chloro-phthalic acid dimethyl ester;dimethyl 4-chloro-benzenedicarboxylate;Dimethyl-4-chloro-phthalat;4-Chlor-phthalsaeure-dimethylester;1,2-Benzenedicarboxylic acid,4-chloro-,dimethyl ester;

Chemical Property of 1,2-BENZENEDICARBOXYLIC ACID,4-CHLORO-,1,2-DIMETHYL ESTER

Chemical Property:

• Boiling Point: 123 °C(Press: 3 Torr)
• PSA: 52.60000
• Density: 1.290±0.06 g/cm3(Predicted)
• LogP: 1.91320

Purity/Quality:

99% ^*data from raw suppliers

1,2-BENZENEDICARBOXYLICACID,4-CHLORO-,1,2-DIMETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-BENZENEDICARBOXYLIC ACID,4-CHLORO-,1,2-DIMETHYL ESTER

There total 10 articles about 1,2-BENZENEDICARBOXYLIC ACID,4-CHLORO-,1,2-DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + monosodium salt of 4-chlorophthalic acid → dimethyl 4-chlorophthalate (58138-38-8)

Guidance literature:

With sulfuric acid; for 48h; Heating / reflux;

Reference yield:

methanol (67-56-1) + benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5) → dimethyl 4-chlorophthalate (58138-38-8) + 3-chlorophthalic acid dimethyl ester (61539-35-3)

Guidance literature:

benzene-1,2-dicarboxylic acid; With chlorine; In water; for 3h;

methanol; for 1.5h; Alkaline conditions;

Reference yield:

2-chloro-1-trimethylsilyloxy-1,3-butadiene (146271-52-5) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 4-chlorophthalate (58138-38-8)

Guidance literature:

With aluminium trichloride; hydroquinone; Yield given. Multistep reaction; 1) toluene, 120 deg C, 15 h, 2) toluene, 120 deg C, 1 h;

DOI:10.1016/S0040-4020(01)88354-X

upstream raw materials:

methanol

4-chlorophthalic acid

2-chloro-1-trimethylsilyloxy-1,3-butadiene

dimethyl acetylenedicarboxylate

Downstream raw materials:

5-chloro-2-(methoxycarbonyl)benzoic acid

1,1'-biphenyl-2,2',3,3'-tetracarboxylic acid

3,3',4,4'-biphenyltetracarboxylic acid tetramethyl ester

1H-indene-1,3(2H)-dione

Refernces

• 1、 -. "Azabicyclic compounds for the treatment of disease". Page 42. . Retrieved 2010/02/06.