Technology Process of Benzonitrile, 4-(trimethylstannyl)-
There total 15 articles about Benzonitrile, 4-(trimethylstannyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methyl iodide;
In
ammonia;
condensation of sodium-dried ammonia into round-bottomed Pyrex flask, addn. of Me3SnCl and Na, then addn. of CNC6H4NMe3I; holding in dark for 0.08 h; quenching by addn. of MeI in excess; evapn. of ammonia, treatment with water, extn. with ether;
DOI:10.1021/om000859p
- Guidance literature:
-
dichloro bis(acetonitrile) palladium(II);
In
N,N-dimethyl-formamide;
byproducts: (CH3)3SnI; Me6Sn2, p-CNC6H4I dissolved in DMF in a flask, catalyst added with stirring, reacted for 10 min at 20°C; water added, extracted with ether, extracts filtered, washed with water, dried with Na2SO4, chromy.(silica gel, hexane/ether 2:1);
- Guidance literature:
-
4-iodobenzonitrile;
With
isopropylmagnesium chloride;
In
tetrahydrofuran; diethyl ether;
at -40 ℃;
for 1h;
trimethyltin(IV)chloride;
In
tetrahydrofuran; diethyl ether;
at -40 - 20 ℃;
DOI:10.1002/anie.201304443
