1-Chloro-4-(4-chlorophenyl)-2-butanol

Base Information

• Chemical Name: 1-Chloro-4-(4-chlorophenyl)-2-butanol
• CAS No.: 59363-13-2
• Molecular Formula: C10H12Cl2O
• Molecular Weight: 219.111
• Hs Code.: 2906299090
• Mol file: 59363-13-2.mol

Synonyms:1-chloro-4-chlorophenyl-2-butanol;

Chemical Property of 1-Chloro-4-(4-chlorophenyl)-2-butanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.87230
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Chloro-4-(4-chlorophenyl)-2-butanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Chloro-4-(4-chlorophenyl)-2-butanol

There total 2 articles about 1-Chloro-4-(4-chlorophenyl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.51%

1-Chloro-4-(chloromethyl)benzene (104-83-6) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-chloro-4-(4-chlorophenyl)-2-butanol (59363-13-2)

Guidance literature:

1-Chloro-4-(chloromethyl)benzene; With iodine; magnesium; In tetrahydrofuran; diethyl ether; at 35 - 37 ℃; for 1h;

epichlorohydrin; In diethyl ether; at 37 ℃; for 1.5h; Temperature; Time;

Reference yield: 57.0%

→ 1-chloro-4-(4-chlorophenyl)-2-butanol (59363-13-2)

Guidance literature:

Reference yield: 99.31%

1H-imidazole (288-32-4) + 1-chloro-4-(4-chlorophenyl)-2-butanol (59363-13-2) → 1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole (67085-11-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 58 - 62 ℃; for 3h; Temperature; Time; Cooling with ice;

upstream raw materials:

1-Chloro-4-(chloromethyl)benzene

epichlorohydrin

Downstream raw materials:

1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole

1-[2-chloro-4-(4-chlorophenyl)-n-butyl]imidazole

butoconazole

Refernces

• 1、 -. "A industrialized production butoconazole nitrate intermediates". Paragraph 0073-0075. . Retrieved 2018/05/24.
• 2、 -. "Butoconazole nitrate industrial production method". Paragraph 0104-0107. . Retrieved 2018/05/16.