2',5'-Dimethoxy-4'-nitrobenzanilide

Base Information

• Chemical Name: 2',5'-Dimethoxy-4'-nitrobenzanilide
• CAS No.: 92-20-6
• Molecular Formula: C15H14 N2 O5
• Molecular Weight: 302.287
• Hs Code.: 2924299090
• European Community (EC) Number: 202-135-2
• DSSTox Substance ID: DTXSID20919403
• Nikkaji Number: J30.940K
• Wikidata: Q82891904
• Mol file: 92-20-6.mol

Synonyms:2',5'-Dimethoxy-4'-nitrobenzanilide;92-20-6;EINECS 202-135-2;Oprea1_426452;DTXSID20919403;N-(2,5-Dimethoxy-4-nitrophenyl)benzenecarboximidic acid

Chemical Property of 2',5'-Dimethoxy-4'-nitrobenzanilide

Chemical Property:

• PSA: 96.87000
• LogP: 3.77150
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 302.09027155
• Heavy Atom Count: 22
• Complexity: 392

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1NC(=O)C2=CC=CC=C2)OC)[N+](=O)[O-]

Technology Process of 2',5'-Dimethoxy-4'-nitrobenzanilide

There total 2 articles about 2',5'-Dimethoxy-4'-nitrobenzanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(2,5-Dimethoxyphenyl)benzamide (135-45-5) → N-(2,5-Dimethoxy-4-nitrophenyl)benzamide (92-20-6)

Guidance literature:

With water; nitric acid; In acetic acid; at 20 ℃; for 1.5h;

DOI:10.1039/a907633f

Reference yield:

benzoyl chloride (98-88-4) + 2,5-dimethoxyaniline (102-56-7,102526-87-4) → N-(2,5-Dimethoxy-4-nitrophenyl)benzamide (92-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate

2: nitric acid / 20 °C

With nitric acid; sodium carbonate;

Reference yield: 89.0%

N-(2,5-Dimethoxy-4-nitrophenyl)benzamide (92-20-6) → N-(4-Amino-2,5-dimethoxyphenyl)benzamide (6268-05-9)

Guidance literature:

With hydrogenchloride; tin; In ethanol; for 3h; Heating;

DOI:10.1039/a907633f

upstream raw materials:

N-(2,5-Dimethoxyphenyl)benzamide

benzoyl chloride

2,5-dimethoxyaniline

Downstream raw materials:

N-(4-Amino-2,5-dimethoxyphenyl)benzamide

N-(2,5-dimethoxy-4-nitrophenyl)thiobenzamide

2,5-dimethoxy-4-nitroaniline

8-Methyl-2-phenylthiazolo<4,5-g>quinoline-4,9-dione

Refernces