4-(Dimethylamino)benzamide

Base Information

• Chemical Name: 4-(Dimethylamino)benzamide
• CAS No.: 6083-47-2
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Hs Code.: 2924299090
• Mol file: 6083-47-2.mol

Synonyms:Benzamide,4-(dimethylamino);4-Dimethylaminobenzamide;4-dimethylamino-benzoic acid amide;4-N,N-dimethylaminobenzamide;4-Dimethylamino-benzoesaeure-amid;p-dimethylaminobenzamide;

Chemical Property of 4-(Dimethylamino)benzamide

Chemical Property:

• Melting Point: 203.5 °C
• Boiling Point: 325.5±25.0 °C(Predicted)
• PKA: 16.89±0.50(Predicted)
• PSA: 46.33000
• Density: 1.123±0.06 g/cm3(Predicted)
• LogP: 1.55180
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

4-(Dimethylamino)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Dimethylamino)benzamide

There total 22 articles about 4-(Dimethylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-cyano-N,N-dimethylaniline (1197-19-9) → 4-(dimethylamino)benzamide (6083-47-2)

Guidance literature:

With [RuH(tBu-PNP(-))(CO)]; water; In tert-butyl alcohol; at 50 ℃; for 20h;

DOI:10.1039/c9sc04624k

Reference yield: 96.3%

4-dimethylamino-benzaldehyde (100-10-7) → 4-(dimethylamino)benzamide (6083-47-2)

Guidance literature:

With ammonia; oxygen; In water; at 150 ℃; for 5h; under 22502.3 Torr;

DOI:10.1039/c2jm34652d

Reference yield: 91.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-nitrobenzamide (619-80-7) → 4-(dimethylamino)benzamide (6083-47-2)

Guidance literature:

With formic acid; triethylamine; In water; tert-butyl alcohol; at 100 ℃; for 28h;

DOI:10.1002/cctc.201701617

upstream raw materials:

4-(dimethylamino)benzoyl chloride

4-aminobenzamide

(E)-4-dimethylaminobenzaldehyde oxime

p-N,N-dimethylaminobenzoic anhydride

Downstream raw materials:

4-(Dimethylamino)benzophenone

4-cyano-N,N-dimethylaniline

auramine O

2-(p-dimethylaminophenyl)benzoxazole

Refernces

• 1、 Wang, Yang,Guo, Wen,Guan, Ai-Lin,Liu, Shuang,Yao, Zi-Jian. "Half-Sandwich Iridium Complexes Based on β-Ketoamino Ligands: Preparation, Structure, and Catalytic Activity in Amide Synthesis". . p. 11514 - 11520. Retrieved 2021/07/31.
• 2、 Chen, Jiajia,Lee, Sunwoo,Xia, Yuanzhi. "Transamidation for the Synthesis of Primary Amides at Room Temperature". supporting information. . Retrieved 2020/05/05.