2-(2-Oxopropyl)cyclohexan-1-one

Base Information

• Chemical Name: 2-(2-Oxopropyl)cyclohexan-1-one
• CAS No.: 6126-53-0
• Molecular Formula: C9H14O2
• Molecular Weight: 154.209
• Hs Code.: 2914299000
• Mol file: 6126-53-0.mol

Synonyms:2-acetonyl-cyclohexanone;2-Acetonyl-cyclohexanon;2-acetonylcyclohexan-1-one;

Chemical Property of 2-(2-Oxopropyl)cyclohexan-1-one

Chemical Property:

• Melting Point: 203-205 °C
• Boiling Point: 91-93 °C(Press: 1.1 Torr)
• PSA: 34.14000
• Density: 1.0235 g/cm3
• LogP: 1.72480

Purity/Quality:

98%Min ^*data from raw suppliers

2-(2-OXOPROPYL)CYCLOHEXANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-Oxopropyl)cyclohexan-1-one

There total 57 articles about 2-(2-Oxopropyl)cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(2-propynyl)cyclohexanone (19823-75-7) → 2-(2-oxopropyl)cyclohexanone (6126-53-0)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); In water; acetonitrile; for 24h; Yields of byproduct given; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(00)96302-0

Reference yield: 92.0%

2-(2-azidoallyl)cyclohexan-1-one → 2-(2-oxopropyl)cyclohexanone (6126-53-0)

Guidance literature:

With tetrafluoroboric acid; water; In acetonitrile; at 15 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b00395

Reference yield: 89.0%

8-methoxy-8-methyl-7-oxabicyclo<4.3.0>heptane (186586-84-5,632322-81-7) → 2-(2-oxopropyl)cyclohexanone (6126-53-0)

Guidance literature:

With jones reagent; In acetone; sonication;

DOI:10.1039/c39950000469

upstream raw materials:

2-methyl-4,5,6,7-tetrahydrobenzofuran

1-(1-Cyclohexen-1-yl)pyrrolidine

1-bromoacetone

2-<2-Bromo-1-(bromomethyl)ethoxy>tetrahydropyran

Downstream raw materials:

2-methyl-4,5,6,7-tetrahydro-1H-indole

2-methyl-1H-indole

2-Methylbenzothiophene

cis-2H-1,3,3a,4,5,6,7,7a-octahydro-7a-methyl-2-indenone

Refernces

• 1、 Anselmo, Manuel,Basso, Andrea,Protti, Stefano,Ravelli, Davide. "Photoredox-Catalyzed Generation of Acetonyl Radical in Flow: Theoretical Investigation and Synthetic Applications". . p. 2493 - 2500. Retrieved 2019/03/08.
• 2、 Buil, Maria Antonia,Calbet, Marta,Castillo, Marcos,Castro, Jordi,Esteve, Cristina,Ferrer, Manel,Forns, Pilar,González, Jacob,López, Sara,Roberts, Richard S.,Sevilla, Sara,Vidal, Bernat,Vidal, Laura,Vilaseca, Pere. "Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists". . p. 102 - 133. Retrieved 2016/03/04.