Carbamic acid, 3-methylphenyl, ethyl ester

Base Information

• Chemical Name: Carbamic acid, 3-methylphenyl, ethyl ester
• CAS No.: 6135-33-7
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• DSSTox Substance ID: DTXSID00335940
• Wikidata: Q82102654
• Mol file: 6135-33-7.mol

Synonyms:Carbamic acid, 3-methylphenyl, ethyl ester;m-Tolylurethan;6135-33-7;SCHEMBL3424143;DTXSID00335940;AKOS002937716;Carbamic acid, 3-methylphenyl-, ethyl ester

Chemical Property of Carbamic acid, 3-methylphenyl, ethyl ester

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)NC1=CC=CC(=C1)C

Technology Process of Carbamic acid, 3-methylphenyl, ethyl ester

There total 9 articles about Carbamic acid, 3-methylphenyl, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-methyl-3-nitrobenzene (99-08-1) + chloroformic acid ethyl ester (541-41-3) → carbamic acid, (3-methyphenyl)-, ethyl ester (6135-33-7)

Guidance literature:

With tin; ammonium chloride; In methanol; at 25 ℃; for 2.5h; Sonication;

DOI:10.1055/s-2002-25338

Reference yield: 68.0%

ethanol (64-17-5) + (1H-benzo-[d][1,2,3]triazol-1-yl)(m-tolyl)methanone (313549-89-2) → carbamic acid, (3-methyphenyl)-, ethyl ester (6135-33-7)

Guidance literature:

With sodium azide; In water; at 90 - 100 ℃; for 4h;

DOI:10.1039/c6ra14131e

Reference yield: 64.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 1-methyl-3-nitrobenzene (99-08-1) → carbamic acid, (3-methyphenyl)-, ethyl ester (6135-33-7)

Guidance literature:

With bis(triphenylphosphine)platinum(II) dichloride; tin(IV) chloride; triethylamine; at 180 ℃; for 4h; under 45600 Torr;

DOI:10.1246/bcsj.56.3343

upstream raw materials:

ethanol

m-tolyl-carboximidoyl chloride

chloroformic acid ethyl ester

1-amino-3-methylbenzene

Downstream raw materials:

Ethyl N-(3-methyl-2,4,6-trinitrophenyl)carbamate

Refernces

• 1、 Wei, Jianping,Li, Fangmei,Xu, Junhui,Peng, Xinhua. "Synthesis and thermal stability of new polynitrostilbenes". . p. 919 - 925. Retrieved 2015/06/25.
• 2、 Wang, Peixue,Ma, Yubo,Liu, Shimin,Zhou, Feng,Yang, Benqun,Deng, Youquan. "N-Substituted carbamate synthesis using urea as carbonyl source over TiO2-Cr2O3/SiO2 catalyst". . p. 3964 - 3971. Retrieved 2015/07/15.