1,4-Dihydronicotinamide mononucleotide

Base Information

• Chemical Name: 1,4-Dihydronicotinamide mononucleotide
• CAS No.: 4229-56-5
• Molecular Formula: C11H17N2O8P
• Molecular Weight: 336.238
• Mol file: 4229-56-5.mol

Synonyms:β-Nicotinamidmononucleotid;β-Nicotinamid-mononucleotid (Reduzierte Form);β-Dihydro-nicotinamid-ribose-5-phosphat;Phosphoric acid mono-[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester;nicotinamide mononucleotide;dihydronicotinamide mononucleotide;β-Dihydronicotinamidmononucleotid;

Chemical Property of 1,4-Dihydronicotinamide mononucleotide

Chemical Property:

• PSA: 172.59000
• LogP: -1.23080

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Dihydronicotinamide mononucleotide

There total 5 articles about 1,4-Dihydronicotinamide mononucleotide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

NADH (58-68-4,443892-10-2) → 1,4-dihydronicotinamide mononucleotide (4229-56-5) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With tris hydrochloride; nicotinamide adenine dinucleotide pyrophosphatase from Escherichia coli strain K₁₂; manganese(ll) chloride; at 37 ℃; for 0.75h; pH=8; Enzymatic reaction;

DOI:10.1096/fj.202001826R

Reference yield:

nicotinamide riboside 5'-monophosphate (75414-16-3) → 1,4-dihydronicotinamide mononucleotide (4229-56-5)

Guidance literature:

With sodium dithionite; Inert atmosphere;

DOI:10.1042/BCJ20160566

Reference yield:

NADH (58-68-4,443892-10-2) → 1,4-dihydronicotinamide mononucleotide (4229-56-5)

Guidance literature:

With ammonium acetate; magnesium chloride; In water; at 48 ℃; for 1h; Enzymatic reaction;

upstream raw materials:

nicotinamide riboside 5'-monophosphate

NADH

nicotinamide mononucleotide

Refernces

• 1、 -. "SYNTHETIC METHOD FOR NMN DERIVATIVE AND MEDICAL APPLICATIONS OF NMN AND ITS DERIVATIVE". Page/Page column 15. . Retrieved 2021/05/29.