2-BROMO-4,5-DIMETHOXYPHENYLACETIC ACID

Base Information

• Chemical Name: 2-BROMO-4,5-DIMETHOXYPHENYLACETIC ACID
• CAS No.: 4697-62-5
• Molecular Formula: C10H11BrO4
• Molecular Weight: 275.099
• Hs Code.: 2918990090
• Mol file: 4697-62-5.mol

Synonyms:Aceticacid, (2-bromo-4,5-dimethoxyphenyl)- (7CI,8CI);(6-Bromo-3,4-dimethoxyphenyl)acetic acid;2-Bromo-4,5-dimethoxybenzeneaceticacid;2-Bromo-4,5-dimethoxyphenylacetic acid;NSC 143407;

Chemical Property of 2-BROMO-4,5-DIMETHOXYPHENYLACETIC ACID

Chemical Property:

• Vapor Pressure: 2.34E-06mmHg at 25°C
• Melting Point: 94 °C
• Refractive Index: 1.558
• Boiling Point: 377.1 °C at 760 mmHg
• PKA: 4.09±0.10(Predicted)
• Flash Point: 181.8 °C
• PSA: 55.76000
• Density: 1.519 g/cm³
• LogP: 2.09340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(2-BROMO-4,5-DIMETHOXY-PHENYL)-ACETIC ACID ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4,5-DIMETHOXYPHENYLACETIC ACID

There total 7 articles about 2-BROMO-4,5-DIMETHOXYPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → 6-bromohomoveratric acid (4697-62-5)

Guidance literature:

With bromine; In dichloromethane;

DOI:10.1055/s-2006-926410

Reference yield:

2-bromo-4,5-dimethoxybenzyl alcohol (54370-00-2) → 6-bromohomoveratric acid (4697-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene; HCl

2: ethanol

3: ethanolic KOH-solution

With hydrogenchloride; potassium hydroxide; ethanol; benzene;

DOI:10.1021/ja01287a039

Reference yield:

2-bromo-4,5-dimethoxyphenylacetonitrile (51655-39-1) → 6-bromohomoveratric acid (4697-62-5)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01287a039

upstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

2-bromo-4,5-dimethoxyphenylacetonitrile

dimethyl sulfate

3,4-dimethoxyphenylacetonitrile

Downstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

N-(2-(benzo[d] [1,3]dioxol-5-yl)ethyl)-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

methyl 2-(2-bromo-4,5-dimethoxyphenyl)acetate

1-[2-(2-bromo-4,5-dimethoxyphenyl)acetyl]-2-phenyl-2,3-dihydropyridin-4-one

Refernces

• 1、 -. "Synthesizing method of oxidized dicentrine". Paragraph 0042-0045. . Retrieved 2019/03/28.
• 2、 -. "Bromated oxidated dicentrine and synthesis method and application thereof". Paragraph 0048-0051. . Retrieved 2019/04/04.