2-Fluoro-5-nitropyridine

Base Information

• Chemical Name: 2-Fluoro-5-nitropyridine
• CAS No.: 456-24-6
• Molecular Formula: C5H3FN2O2
• Molecular Weight: 142.089
• Hs Code.: 2933399090
• European Community (EC) Number: 207-260-6
• NSC Number: 26280
• DSSTox Substance ID: DTXSID70196565
• Nikkaji Number: J149.529A
• Wikidata: Q72475428
• Mol file: 456-24-6.mol

Synonyms:2-Fluoro-5-nitropyridine;456-24-6;6-Fluoro-3-nitropyridine;PYRIDINE, 2-FLUORO-5-NITRO-;2-fluoro-5-nitro-pyridine;MFCD03095059;EINECS 207-260-6;2-fluor-5-nitropyridin;5-nitro-2-fluoropyridine;NSC26280;SCHEMBL1163154;DTXSID70196565;C5-H3-F-N2-O2;BCP23147;CS-D0968;BBL100718;NSC 26280;NSC-26280;STL554512;2-Fluoro-5-nitropyridine, AldrichCPR;AKOS005063588;AKOS005145591;AB13439;AC-5942;AS-14966;SY010502;A7182;AM20051198;F0983;FT-0647780;EN300-104104;Q-103368

Chemical Property of 2-Fluoro-5-nitropyridine

Chemical Property:

• Vapor Pressure: 0.0686mmHg at 25°C
• Melting Point: 142-144 °C
• Refractive Index: 1.538
• Boiling Point: 237.5 °C at 760 mmHg
• PKA: -4.47±0.10(Predicted)
• Flash Point: 97.5 °C
• PSA: 58.71000
• Density: 1.439 g/cm³
• LogP: 1.65210
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Moisture Sensitive
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 142.01785550
• Heavy Atom Count: 10
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1[N+](=O)[O-])F
• Uses: It is used in the preparation of nitropyridines by nitration of pyridines with nitric acid. 2-Fluoro-5-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 2-Fluoro-5-nitropyridine

There total 10 articles about 2-Fluoro-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 2-Fluoro-5-nitropyridine (456-24-6)

Guidance literature:

With potassium fluoride; In water; dimethyl sulfoxide; at 20 ℃;

Reference yield: 92.0%

2-chloro-5-nitropyridine (4548-45-2) → 2-Fluoro-5-nitropyridine (456-24-6)

Guidance literature:

With 18-crown-6 ether; tetramethlyammonium chloride; cesium fluoride; In acetonitrile; at 60 ℃; for 16h; Glovebox;

DOI:10.1021/acs.joc.0c02845

Reference yield: 83.0%

2-chloro-5-nitropyridine (4548-45-2) → 2-Fluoro-5-nitropyridine (456-24-6) + 5-Nitro-1-(5-nitro-2-pyridyl)-2-pyridone (63913-20-2)

Guidance literature:

With cesium fluoride; In various solvent(s); at 130 ℃; for 18h;

DOI:10.1039/p19960002221

upstream raw materials:

5-nitro-pyridin-2-ylamine

2-chloro-5-nitropyridine

2-fluoropyridine

5,5'-dinitro-2,2'-disulfanediyl-bis-pyridine

Downstream raw materials:

2-methoxy-5-nitropyridine

2-fluoro-5-aminopyridine

N-(5-nitro-[2]pyridyl)-phenylalanine

{(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methyl}-(5-nitro-pyridin-2-yl)-amine

Refernces

• 1、 Bland, Douglas C.,Lee, So Jeong,Morales-Colón, Mariá T.,Sanford, Melanie S.,Scott, Peter J. H.,See, Yi Yang. "Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination". supporting information. p. 4493 - 4498. Retrieved 2021/06/28.
• 2、 -. "PROCESS FOR FLUORINATING COMPOUNDS". Page/Page column 29; 33; 35. . Retrieved 2017/02/28.