O-(2-phenylethyl)hydroxylamine

Base Information

• Chemical Name: O-(2-phenylethyl)hydroxylamine
• CAS No.: 4732-11-0
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Mol file: 4732-11-0.mol

Synonyms:

Chemical Property of O-(2-phenylethyl)hydroxylamine

Chemical Property:

• Vapor Pressure: 0.0133mmHg at 25°C
• Boiling Point: 259°Cat760mmHg
• Flash Point: 124.2°C
• Density: 1.036g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O-(2-phenylethyl)hydroxylamine

There total 9 articles about O-(2-phenylethyl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-phenethoxyisoindoline-1,3-dione (92856-14-9) → O-(2-phenylethyl)hydroxylamine (4732-11-0)

Guidance literature:

With hydrazine hydrate; In methanol; for 4h; Heating;

DOI:10.1021/jm9607921

Reference yield:

C13H19NO3 (288141-85-5) → O-(2-phenylethyl)hydroxylamine (4732-11-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.0333333h;

Reference yield:

2-phenylethanol (60-12-8) → O-(2-phenylethyl)hydroxylamine (4732-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 16 h / Ambient temperature

2: 85 percent / hydrazine monohydrate / methanol / 4 h / Heating

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1021/jm9607921

upstream raw materials:

N-<2-Phenylethoxy>-carbaminsaeure-ethylester

2-phenethoxyisoindoline-1,3-dione

2-phenylethanol

1-phenyl-2-bromoethane

Downstream raw materials:

C₁₅H₂₀N₂O₃S₂

C₁₆H₂₂N₂O₃S₂

C₁₇H₂₄N₂O₃S₂

C₁₇H₂₄N₂O₃S₂

Refernces

• 1、 -. "OXIME ETHER COMPOUNDS". Page/Page column 43; 44. . Retrieved 2019/02/25.
• 2、 Kim, In-Hae,Lee, In-Hee,Nishiwaki, Hisashi,Hammock, Bruce D.,Nishi, Kosuke. "Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase". . p. 1163 - 1175. Retrieved 2014/02/14.