TERT-BUTYL N-(2-THIENYL)CARBAMATE

Base Information

• Chemical Name: TERT-BUTYL N-(2-THIENYL)CARBAMATE
• CAS No.: 56267-50-6
• Molecular Formula: C9H13NO2S
• Molecular Weight: 199.274
• Hs Code.: 2934999090
• Mol file: 56267-50-6.mol

Synonyms:tert-Butyl thien-2-ylcarbamate;tert-Butyl thiophen-2-ylcarbamate;(tert-Butoxy)-N-(2-thienyl)carboxamide;Thiophen-2-ylcarbamic acid tert-butylester;tert-Butyl 2-thienylcarbamate;

Chemical Property of TERT-BUTYL N-(2-THIENYL)CARBAMATE

Chemical Property:

• Vapor Pressure: 0.0432mmHg at 25°C
• Melting Point: 151 °C
• Refractive Index: 1.562
• Boiling Point: 238.1 °C at 760 mmHg
• PKA: 13.63±0.70(Predicted)
• Flash Point: 97.8 °C
• PSA: 66.57000
• Density: 1.186 g/cm³
• LogP: 3.16810
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.0% Min., ^*data from raw suppliers

tert-ButylN-(2-Thienyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL N-(2-THIENYL)CARBAMATE

There total 8 articles about TERT-BUTYL N-(2-THIENYL)CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-thiophenylcarboxylic acid (527-72-0) + tert-butyl alcohol (75-65-0) → tert-butyl (2-thienyl)carbamate (56267-50-6)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; for 12h; Heating;

DOI:10.1021/jm00109a011

Reference yield: 58.0%

C10H13NO4S → tert-butyl (2-thienyl)carbamate (56267-50-6)

Guidance literature:

With caesium carbonate; In acetonitrile; at 100 ℃; for 1h; Sealed tube;

DOI:10.1021/acs.joc.8b00970

Reference yield:

thiophen-2-ylamine (616-46-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (2-thienyl)carbamate (56267-50-6)

Guidance literature:

In tetrahydrofuran; water; for 4h;

DOI:10.1021/ol052120n

upstream raw materials:

2-bromothiophene

2-thiophenylcarboxylic acid

tert-butyl alcohol

Acetyl-thiophen-2-yl-carbamic acid tert-butyl ester

Downstream raw materials:

2-acetylaminothiophene

5-bromothieno[2,3-b]pyridine

2-aminothiophene hydrochloride

thiophen-2-ylamine

Refernces

• 1、 -. "CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES". Page/Page column 100. . Retrieved 2010/05/14.
• 2、 -. "Imidazopyrazines as protein kinase inhibitors". Page/Page column 77. . Retrieved 2010/11/27.