Technology Process of Magnesium chloride (2S,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-ide (1/1/1)
There total 1 articles about Magnesium chloride (2S,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-ide (1/1/1) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ethyl bromide; magnesium;
In
tetrahydrofuran;
1.) 4 h, 50 degC, 2.) 1 h, 70 deg C;
- Guidance literature:
-
In
tetrahydrofuran; diethyl ether;
exclusion of air and moisture; soln. of Sn-compd. in Et2O added dropwise over a period of 5h at 0°C to a vigorously stirred soln. of Mg-compd. in THF, stirred at room temp. for 48h, treated with water at 0°C, stirred for 1h at room temp.; dried over anhydrous Na2SO4, solvent removed, distn.; elem. anal.;
DOI:10.1016/0022-328X(89)87177-3
- Guidance literature:
-
In
diethyl ether; benzene;
N2-atmosphere; dropwise addn. of Grignard reagent (in ether) to Sn-compd. (in C6H6); addn. of 10% HCl, washing of org. layer, drying, evapn.;
DOI:10.1016/0022-328X(95)05323-H
