5-Bromo-6-chloro-2-(methylthio)-4-pyrimidinamine

Base Information

• Chemical Name: 5-Bromo-6-chloro-2-(methylthio)-4-pyrimidinamine
• CAS No.: 63931-22-6
• Molecular Formula: C5H5BrClN3S
• Molecular Weight: 254.53500
• Hs Code.: 2933599090
• Mol file: 63931-22-6.mol

Synonyms:4-amino-5-bromo-6-chloro-2-methylthiopyrimidine;5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine;

Chemical Property of 5-Bromo-6-chloro-2-(methylthio)-4-pyrimidinamine

Chemical Property:

• Melting Point: 240-241℃
• Boiling Point: 379.8±37.0 °C(Predicted)
• PKA: -0?+-.0.10(Predicted)
• PSA: 77.10000
• Density: 1.90
• LogP: 2.77780
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-6-chloro-2-(methylthio)-4-pyrimidinamine

There total 3 articles about 5-Bromo-6-chloro-2-(methylthio)-4-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-6-chloro-2-methylthiopyrimidine (1005-38-5) → 5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine (63931-22-6)

Guidance literature:

With bromine; acetic acid;

Reference yield:

bromine (7726-95-6) + 4-amino-6-chloro-2-methylthiopyrimidine (1005-38-5) → 5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine (63931-22-6)

Guidance literature:

Reference yield:

→ 5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine (63931-22-6)

Guidance literature:

4-Amino-6-chlor-2-methylthiopyrimidin, Br2, NaHCO3;

upstream raw materials:

4-amino-6-chloro-2-methylthiopyrimidine

bromine

Refernces

• 1、 -. "NEW PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS (PDE-10)". Page/Page column 26. . Retrieved 2014/08/07.