1-PYRIDIN-4-YL-ETHYLAMINE

Base Information

• Chemical Name: 1-PYRIDIN-4-YL-ETHYLAMINE
• CAS No.: 50392-78-4
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 29333990
• Mol file: 50392-78-4.mol

Synonyms:4-(1-Aminoethyl)pyridine;

Chemical Property of 1-PYRIDIN-4-YL-ETHYLAMINE

Chemical Property:

• Vapor Pressure: 0.109mmHg at 25°C
• Refractive Index: n20/D 1.5347
• Boiling Point: 221.1 °C at 760 mmHg
• PKA: 8.28±0.29(Predicted)
• Flash Point: 108.2 °C
• PSA: 38.91000
• Density: 1.018 g/cm³
• LogP: 1.80160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Water Solubility.: Soluble in water

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Pyridin-4-yl-ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, Xi
• Hazard Codes: T,Xi
• Statements: 25-37/38-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1-(4-Pyridyl)ethylamine is used as a pharmaceutical intermediates

Technology Process of 1-PYRIDIN-4-YL-ETHYLAMINE

There total 14 articles about 1-PYRIDIN-4-YL-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyridine-4-carbonitrile (100-48-1) + methylmagnesium bromide (75-16-1) → 1-pyridin-4-yl-ethylamine (50392-78-4)

Guidance literature:

pyridine-4-carbonitrile; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 100 ℃; for 0.166667h; Microwave irradiation;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; diethyl ether; for 0.0833333h;

DOI:10.1016/j.tetlet.2009.04.081

Reference yield: 92.0%

pyridine-4-carbaldehyde (872-85-5) → 1-pyridin-4-yl-ethylamine (50392-78-4)

Guidance literature:

Pd on carbon;

Reference yield: 81.0%

methyl (4-pyridyl) ketone (1122-54-9) → 1-pyridin-4-yl-ethylamine (50392-78-4)

Guidance literature:

With formic acid; C₂₆H₃₄ClIrN₄O; ammonium formate; In methanol; at 80 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.9b01565

upstream raw materials:

4-(1,1-dinitro-ethyl)-pyridine

4-acetylpyridine oxime

ethanol

rac-1-(pyridin-4-yl)ethanol

Downstream raw materials:

C₂₆H₂₄ClN₃O₃

C₂₁H₂₀FN₃O₃S

1-(1-(4-chlorobenzyl)-1H-indole-2-carbonyl)-N-(1-(pyridin-4-yl)ethyl)piperidine-4-carboxamide

Refernces

• 1、 -. "Pyridine methylamine compound and preparation method thereof". Paragraph 0132-0138. . Retrieved 2021/08/28.
• 2、 Tanaka, Kouichi,Miki, Takashi,Murata, Kunihiko,Yamaguchi, Ayumi,Kayaki, Yoshihito,Kuwata, Shigeki,Ikariya, Takao,Watanabe, Masahito. "Reductive amination of ketonic compounds catalyzed by Cp*Ir(III) complexes bearing a picolinamidato ligand". . p. 10962 - 10977. Retrieved 2019/09/03.