tris(trimethylsilyl)silicon

Base Information

• Chemical Name: tris(trimethylsilyl)silicon
• CAS No.: 7239-81-8
• Molecular Formula: C6H5 N3 S
• Molecular Weight: 151.192
• Hs Code.: 2933990090
• Mol file: 7239-81-8.mol

Synonyms:1H-Imidazo[4,5-c]pyridine-2-thiol(7CI,8CI); 1,3-Dihydroimidazo[4,5-c]pyridine-2-thione;3H-Imidazo[4,5-c]pyridine-2-thiol

Chemical Property of tris(trimethylsilyl)silicon

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 80.37000
• Density: g/cm³
• LogP: 1.24660
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3H-imidazo[4,5-c]pyridine-2-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tris(trimethylsilyl)silicon

There total 8 articles about tris(trimethylsilyl)silicon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon disulfide (75-15-0,12122-00-8) + 3,4-diaminopyridine (54-96-6) → 1H-imidazo[4,5-c]pyridine-2(3H)-thione (7239-81-8)

Guidance literature:

In pyridine; for 5h; Heating;

DOI:10.1007/BF00475602

Reference yield: 90.0%

3,4-diaminopyridine (54-96-6) + potassium ethyl xanthogenate (140-89-6) → 1H-imidazo[4,5-c]pyridine-2(3H)-thione (7239-81-8)

Guidance literature:

In pyridine; water; for 5h; Heating;

DOI:10.1007/BF00475602

Reference yield: 90.0%

3,4-diaminopyridine (54-96-6) + methyl (N-(4-methylphenyl))dithiocarbamate (13037-22-4) → 2-mercapto-1H-imidazo[4,5-c]pyridine (7239-81-8)

Guidance literature:

In N,N-dimethyl-formamide; for 5h; Heating;

DOI:10.1055/s-1985-35505

upstream raw materials:

3,4-diaminopyridine

methyl (N-(4-methylphenyl))dithiocarbamate

carbon disulfide

potassium ethyl xanthogenate

Downstream raw materials:

2-methylthioimidazo<4,5-c>pyridine

Refernces

• 1、 Chang, Lei,Lee, Sang-Yong,Leonczak, Piotr,Rozenski, Jef,De Jonghe, Steven,Hanck, Theodor,Müller, Christa E.,Herdewijn, Piet. "Imidazopyridine- and purine-thioacetamide derivatives: Potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1)". . p. 10080 - 10100. Retrieved 2015/02/05.
• 2、 -. "Imidazo(4,5-C)pyridines as antiosteoporotic agents". . . Retrieved 2008/06/13.