Thiophene-2-acetamide

Base Information

• Chemical Name: Thiophene-2-acetamide
• CAS No.: 4461-29-4
• Molecular Formula: C6H7NOS
• Molecular Weight: 141.194
• Hs Code.: 2934999090
• European Community (EC) Number: 224-714-9
• UNII: CP6UEJ81DK
• DSSTox Substance ID: DTXSID70196247
• Nikkaji Number: J25.373A
• Wikidata: Q83069307
• Mol file: 4461-29-4.mol

Synonyms:THIOPHENE-2-ACETAMIDE;4461-29-4;2-(thiophen-2-yl)acetamide;2-Thiopheneacetamide;2-thiophen-2-ylacetamide;Thiophen-2-acetamide;2-(2-thienyl)acetamide;CP6UEJ81DK;EINECS 224-714-9;MFCD00017556;thiolacet-amide;(2-thienyl)acetamide;UNII-CP6UEJ81DK;2-thiophen-2-yl-acetamide;SCHEMBL114600;DTXSID70196247;GEO-03237;STK416868;AKOS000291440;SS-3258;CS-0149944;FT-0635310;D85917;EN300-250046;A854372;W-202787

Chemical Property of Thiophene-2-acetamide

Chemical Property:

• Vapor Pressure: 0.000207mmHg at 25°C
• Melting Point: 145oC
• Boiling Point: 327°Cat760mmHg
• Flash Point: 151.6°C
• PSA: 71.33000
• Density: 1.254g/cm³
• LogP: 1.47620
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly, Sonicated), Methanol (Slightly)
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 141.02483502
• Heavy Atom Count: 9
• Complexity: 116

Purity/Quality:

98%,99%, ^*data from raw suppliers

Thiophene-2-acetamide ^*data from reagent suppliers

Safty Information:

• Statements: 22
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

• Canonical SMILES: C1=CSC(=C1)CC(=O)N
• Uses: 2-(Thiophen-2-yl)acetamide is used in preparation of [18F]Maleimide-based Glycogen synthase kinase-3β ligands for positron emission tomography imaging.

Technology Process of Thiophene-2-acetamide

There total 16 articles about Thiophene-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

2-Acetylthiophene (88-15-3,97511-16-5) → 2-(thiophen-2-yl)acetamide (4461-29-4)

Guidance literature:

With ammonium hydroxide; sulfur; In ethanol; at 120 ℃; for 8h; under 600.06 - 15001.5 Torr; Pressure; Temperature;

Reference yield: 94.0%

2-cyanomethylthiophene (20893-30-5) → 2-(thiophen-2-yl)acetamide (4461-29-4)

Guidance literature:

With [OsCl₂(η⁶-p-cymene)(PMe₂OH)]; water; at 80 ℃; for 0.5h; Catalytic behavior; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201703481

Reference yield: 83.0%

2-ally-2-methyl thiopheneacetic acid + rac-Ala-OMe (7625-53-8,10065-72-2,21705-13-5) → 2-(thiophen-2-yl)acetamide (4461-29-4)

Guidance literature:

In ethyl acetate;

upstream raw materials:

2-vinylthiophene

2-cyanomethylthiophene

2-Acetylthiophene

2-thienylacetic acid chloride

Downstream raw materials:

2-cyanomethylthiophene

2-Aminomethylthiophene

2-(thiophen-2-yl)-N-(o-tolyl)acetamide

2-(thiophen-2-yl)-N-(p-tolyl)acetamide

Refernces

• 1、 Bobal, Pavel,Otevrel, Jan,Svestka, David. "One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles". . p. 25029 - 25045. Retrieved 2020/07/14.
• 2、 -. "Corresponding amine nitrile and method of manufacturing thereof". Paragraph 0138; 0139; 0140; 0151; 0152. . Retrieved 2018/05/07.