1-Methyl-1,2,3-triazole

Base Information

• Chemical Name: 1-Methyl-1,2,3-triazole
• CAS No.: 16681-65-5
• Molecular Formula: C3H5N3
• Molecular Weight: 83.0928
• Hs Code.: 2933990090
• Mol file: 16681-65-5.mol

Synonyms:1-Methyl-1,2,3-triazole;1-Methyl-1H-1,2,3-triazole;1-Methyl-1H-v-triazole;

Chemical Property of 1-Methyl-1,2,3-triazole

Chemical Property:

• Boiling Point: 149.7 °C at 760 mmHg
• PKA: 1.40±0.10(Predicted)
• Flash Point: 44.4 °C
• PSA: 30.71000
• Density: 1.17g/cm³
• LogP: -0.18490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

1-Methyl-1,2,3-triazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An azole compound used for binding affinity with various cytochrome P 450 (CYP) proteins.

Technology Process of 1-Methyl-1,2,3-triazole

There total 18 articles about 1-Methyl-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Toluene-4-sulfonate3-(4-methoxy-benzyl)-1-methyl-3H-[1,2,3]triazol-1-ium; → 1-methyl-1,2,3-triazole (16681-65-5)

Guidance literature:

With sulfuric acid; at 120 ℃; for 1h;

Reference yield: 83.7%

1,2,3-triazole (288-36-8) + methyl iodide (74-88-4) → 1-methyl-1,2,3-triazole (16681-65-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/cg501564j

Reference yield: 78.0%

1 ,2,3-Triazole (288-36-8,288-35-7) + methyl iodide (74-88-4) → 1-methyl-1,2,3-triazole (16681-65-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 3h;

upstream raw materials:

diazomethane

1,2,3-triazole

dimethyl sulfate

1-methyl-1H-1,2,3-triazole-4-carboxylic acid

Downstream raw materials:

4-bromo-1-methyl-1H-1,2,3-triazole

3-methyl-1,2,3-triazole-1-oxide

1-methyl-1H-1,2,3-triazole-5-carbaldehyde

cis-(1S)-N-methyl-7-(5-(N⁽¹⁾methyl-1,2,3-triazolyl))-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Refernces

• 1、 Brehm, Martin,Kressler, J?rg,Pulst, Martin,Radicke, Julian,Sebastiani, Daniel,Shaabani, Farzaneh. "Dissolving cellulose in 1,2,3-triazolium-and imidazolium-based ionic liquids with aromatic anions". . . Retrieved 2020.
• 2、 Bousrez, Guillaume,Renier, Olivier,Kelley, Steven P.,Adranno, Brando,Tahavori, Elnaz,Titi, Hatem M.,Smetana, Volodymyr,Tang, Si-Fu,Mudring, Anja-Verena,Rogers, Robin D.. "Ready Access to Anhydrous Anionic Lanthanide Acetates by Using Imidazolium Acetate Ionic Liquids as the Reaction Medium". supporting information. p. 13181 - 13189. Retrieved 2021/08/16.