Methyl piperidine-3-carboxylate

Base Information

• Chemical Name: Methyl piperidine-3-carboxylate
• CAS No.: 50585-89-2
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Hs Code.: 29333990
• Mol file: 50585-89-2.mol

Synonyms:Nipecoticacid, methyl ester (7CI);Methyl 3-piperidinecarboxylate;Methyl nipecotate;NSC 522506;3-Piperidinecarboxylicacid, methyl ester;

Chemical Property of Methyl piperidine-3-carboxylate

Chemical Property:

• Boiling Point: 193.8 °C at 760 mmHg
• PKA: 9.28±0.10(Predicted)
• Flash Point: 71 °C
• PSA: 38.33000
• Density: 1.021 g/cm³
• LogP: 0.48780
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

≥98% ^*data from raw suppliers

MethylPiperidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl piperidine-3-carboxylate

There total 15 articles about Methyl piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + nipecotic acid (498-95-3,262853-93-0) → 3-methoxycarbonylpiperidine (50585-89-2)

Guidance literature:

With oxalyl dichloride; at 0 ℃; for 1h;

DOI:10.1002/ejoc.200800972

Reference yield: 45.0%

methyl 3-pyridinecarboxylate (93-60-7) → 3-methoxycarbonylpiperidine (50585-89-2)

Guidance literature:

With perchloric acid; hydrogen; platinum(IV) oxide; In methanol; for 15h; under 2844.3 Torr;

DOI:10.1021/ja00343a022

Reference yield:

1-(3-methyl-2-butenyl)-3-carbomethoxypyridinium perchlorate → 3-methoxycarbonylpiperidine (50585-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.5 percent / methanol / 1.5 h / Irradiation

2: 45 percent / H₂, HClO₄ / PtO₂ / methanol / 15 h / 2844.3 Torr

With perchloric acid; hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1021/ja00343a022

upstream raw materials:

methyl 3-pyridinecarboxylate

nipecotic acid

methanol

methyl iodide

Downstream raw materials:

dihydroarecoline

nipecotic acid

3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate

methyl 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)piperidine-3-carboxylate

Refernces

• 1、 Beller, Matthias,Chandrashekhar, Vishwas G.,Jagadeesh, Rajenahally V.,Kreyenschulte, Carsten,Murugesan, Kathiravan. "A General Catalyst Based on Cobalt Core–Shell Nanoparticles for the Hydrogenation of N-Heteroarenes Including Pyridines". supporting information. p. 17408 - 17412. Retrieved 2020/08/21.
• 2、 -. "CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY". Page/Page column 35. . Retrieved 2016/09/26.