Cycloheptanecarbonyl chloride

Base Information

• Chemical Name: Cycloheptanecarbonyl chloride
• CAS No.: 6557-86-4
• Molecular Formula: C8H13ClO
• Molecular Weight: 160.644
• Hs Code.: 2916209090
• Mol file: 6557-86-4.mol

Synonyms:cycloheptaneacarbonyl chloride;acid chloride of cycloheptanecarboxylic acid;cycloheptanoyl chloride;cycloheptanecarboxyl chloride;cycloheptane carboxylic acid chloride;

Chemical Property of Cycloheptanecarbonyl chloride

Chemical Property:

• PSA: 17.07000
• LogP: 2.72220

Purity/Quality:

99.90% ^*data from raw suppliers

Cycloheptanecarbonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cycloheptanecarbonyl chloride

There total 5 articles about Cycloheptanecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

cycloheptanoic acid (1460-16-8) → cycloheptanecarbonyl chloride (6557-86-4)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 2.58333h; Heating;

DOI:10.1021/ja012427r

Reference yield:

oxalyl dichloride (79-37-8) + cycloheptanoic acid (1460-16-8) → cycloheptanecarbonyl chloride (6557-86-4)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + cycloheptanol (502-41-0) → cycloheptanecarbonyl chloride (6557-86-4)

Guidance literature:

In dichloromethane;

DOI:10.1016/j.ejmech.2020.113116

upstream raw materials:

diethyl cycloheptane-1,1-dicarboxylate

cycloheptanoic acid

oxalyl dichloride

bis(trichloromethyl) carbonate

Downstream raw materials:

N-(cycloheptylcarbonyl)-D-phenylalnine

cycloheptanecarboxaldehyde

cycloheptanehydroxamic acid

Cycloheptanecarboxylic acid cyclohexyl-hydroxy-amide

Refernces

• 1、 Gado, Francesca,Mohamed, Kawthar A.,Meini, Serena,Ferrisi, Rebecca,Bertini, Simone,Digiacomo, Maria,D'Andrea, Felicia,Stevenson, Lesley A.,Laprairie, Robert B.,Pertwee, Roger G.,Manera, Clementina. "Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor". . . Retrieved 2020/12/29.
• 2、 Gado, Francesca,Di Cesare Mannelli, Lorenzo,Lucarini, Elena,Bertini, Simone,Cappelli, Elena,Digiacomo, Maria,Stevenson, Lesley A.,Macchia, Marco,Tuccinardi, Tiziano,Ghelardini, Carla,Pertwee, Roger G.,Manera, Clementina. "Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief". . p. 276 - 287. Retrieved 2018/07/21.